Clomid (clomiphene) or Nolvadex (tamoxifen), which is better?
In this article we will try to resolve doubts about the choice between the two drugs, as well as find the differences: Clomid and Nolvadex.
Clomiphene citrate (available in pharmacies under the brand names Clomid, Clomid) and tamoxifen (brand name Nolvadex) is antiestrogen belonging to the same group trifeniletilenov. They are structurally similar and are classified as selective modulators of estrogen receptors with mixed agonistic and antagonistic properties. This means that in certain tissue, they block the action of estrogen by binding to a receptor, while in other tissues could act as a real estrogen receptors activating. In men, both drugs act as anti-estrogens in their ability to interfere with estrogen negative feedback on the hypothalamus and stimulate the increased production of GnRH (gonadotropin-releasing hormone). This will result in increased production of luteinizing hormone by the pituitary gland, which in turn can increase the production of testosterone by the testes. This makes both drugs, but for some reason bodybuilders continue to think that only good for Clomid testosterone stimulation.
Studies conducted in the late ’70s in the University of Ghent in Belgium make clear the advantages of Nolvadex over Clomid to increase testosterone levels . Researchers have looked at the effect of Nolvadex and Clomid on the endocrine system healthy men, as well as those who have suffered a small amount of spermatozoids (oligospermia). also found that Nolvadex when used for 10 days at a dosage of 20mg per day increased testosterone in the serum 142% of the initial level that was comparable with the effect of Clomid 150mg per day over the same period of time (an increase in testosterone levels were slightly but not significantly greater with Clomid). We must remember that this is the effect of three 50mg tablets of Clomid. At about the same price 50mg Clomid and 20mg Nolvadex we can already see a difference in relation to the price / benefit result in Nolvadex.
Clomid (clomiphene) or Nolvadex (tamoxifen): difference
Clomid (Clomid) acts on the estrogen receptors in the pituitary and ovaries. By linking estrogen receptors in the pituitary gland, Clomid breaks a negative feedback mechanism, ie, if usually estrogen, acting on the pituitary gland, reduce the production of FSH and LH , when taking Clomid does not happen. Directly on blood levels of estrogen Clomid does not work.
Nolvadex (tamoxifen) also has no effect on the blood level of estrogens because its mechanism of action is also reduced to the estrogen receptor blockade, including the pituitary gland. However, Clomid is a more selective (selective) blocker and Nolvadex – less selective. If Clomid binds to estrogen receptors in the pituitary and preferably testes Nolvadex then contacting them almost in the entire organism. The exception is the bone where clomid and tamoxifen contrary to activate estrogen receptors.
Thus, Clomid acts as an estrogen antagonist and eliminates their inhibitory effect on the hypothalamus and pituitary gland, contributing to a more rapid recovery of their functions. Nolvadex blocks the receptors in almost all tissues and helps to ensure that the body began to rebuild its own testosterone. Importantly, Nolvadex capable of blocking estrogen receptors in the pituitary less than Clomid.
Tamoxifen has drawbacks: quite toxic (sometimes it manifests itself loss of appetite and nausea, increased risk of thrombosis). Tamoxifen increases the number of receptors of progesterone , so it can not be used, if the rate is based on progestin drugs ( nandrolone, trenbolone). In this case, you should use clomiphene.
The general conclusion
Nolvadex (tamoxifen) is preferred option compared to Clomid (clomiphene) because:
- Despite minimal effect on the pituitary gland, Tamoxifen has the same ability to restore the level of testosterone as Clomid and
- Tamoxifen blocks the effects of estrogen in the body, including the pituitary and hypothalamus, which means that it will not only contribute to the restoration of testosterone secretion, but also prevent fluid retention in the body.
- Tamoxifen significantly cheaper than Clomid
- Tamoxifen reduces the level of cholesterol, which is important in the use of steroids
- Clomid increases the level of globulin, which binds to testosterone, which adversely affects the set weight.
- Both drugs inhibit the production of IGF-1
- Directly suppress testicular function
- Increase sex hormone binding globulin
- Increase the concentration of estrogen in some times
- Causes of visual impairment with prolonged use of
The most efficient in the cycle of use of aromatase inhibitors, among which the most popular Proviron, because this drug has no adverse effect on the secretion of growth hormone and anabolic hormone increases the concentration in the blood by inhibiting the aromatization. In the last week of the cycle , and 2 weeks after tamoxifen should be used as the main component of PCT If no Proviron, Nolvadex has to start receiving 2 week steroid cycle, and ends 2-3 weeks after the end of the cycle, the average dose of 10-20 mg per day. I would like to pay special attention to the common misconception that anti-estrogens is recommended to drink after a cycle. Estrogen level rises at the end of the first week of the cycle, so from that moment you need to start the reception!
If used anabolic drugs, which are not subject to aromatization necessity disappears aromatase inhibitors, whereas tamoxifen activated only at the end of the cycle. Read more best cycles of steroids .
These drugs included in the list of banned doping agents. Detection time is 3-6 months depending on the detection method .
- Clomiphene citrate tablets
- Clomid (Egis, Hungary)
- Promifen on Alpha Pharma
- Clomed Balkan is Pharmaceuticals is
- Clomid capsules British Dispensary
- Clomitabs G-Tech Pharmaceuticals
- Clomiphene Genesis
- Clomidol Lyka Labs’
- Clomifene Radjay Pharmaceuticals is
- Clomiver Vermodje
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