Thyroxine (Levothyroxine, of L-thyroxine, tetraiodothyronine, T4) – the main hormone of the thyroid gland. Thyroxine maloaktiven biologically using special enzyme is converted in the body into a more active form – triiodothyronine. Thyroxine is used in medicine for the treatment of hypothyroidism, thyroxine also is widely used in bodybuilding as a means for weight loss.
Analogs thyroxine
Triiodothyronine (T3) or liothyronine – often used for weight loss instead of thyroxine, mechanism of action, they are almost identical. Triiodothyronine is available under the trade names Cytomel, Triakana and others. In the sports environment is popular brand of Tsitover Vermodje. In Russia, T3 pharmacies available.
What is the difference between T3 and T4
Thyroid gland secretes mainly T4 (thyroxine) – this in itself has poor hormone biological activity in tissues but it is converted into the more active form T3 (triiodothyronine or Cytomel) using selenium-dependent enzyme monodeiodinase. T3 in turn has a major biological effect. Thus, T4 may assume a prohormone that is converted in tissue to the main hormone T3. A detailed description here .
Many resources, triiodothyronine is considered the best option, but research shows otherwise. Quote of the clinical pharmacology of Goodman, the last 12 of the 2010 edition – the most authoritative book on pharmacology in the world:
Liothyronine is less desirable for chronic replacement therapy due to the requirement for more frequent dosing (plasma t1 / 2 0.75 days =), Higher cost, and the transient elevations of serum T3 Concentrations the above the normal range . Addition with In, Organs That express the use of the type 2 the Locally deiodinase generated T3 in addition to plasma T3, and hence there is Theoretical sinking concern for These Organs That will of not Maintain Physiological intracellular T3 a levels in the plasma convulsive absence of the T4.
T3 creates an undesirable concentration fluctuations
Fabrics used deiodinase type 2 further triiodothyronine, which is formed inside of the T4 cells. This means that the intracellular levels of T3 in these tissues will be lower, even if the concentration of thyroxine remains unchanged (while taking the drug and for burning fat it is below the norm). From any source can be found, that is synthesized in the adipose tissue of type 2 deiodinase.
According to the athletes, the T4 has a less destructive effect on the muscles.
25-100 mg / day of T3 equivalent ≈300 mg / day T4
From the arguments above, it follows that thyroxine is preferable to burn fat, at least three criteria. In rare cases, T4 shows low efficiency as on the background of a low-carb diet reduced the level of its conversion into T3.
Reduced thyroid function (occurs when long rates and very high doses of thyroxine, in the use of recommended doses, function is restored in 3-4 weeks)
Allergic rash
Detailed description of the side effects can be found in the instructions. Furthermore, you need a specialist consultation to identify contraindications.
Many women and bodybuilders resort to the use of thyroxine as a means for weight loss. Thyroxine has a powerful fat burning effect, increases the calorie consumption and metabolism. His popularity has declined in recent years due to the negative impact on the heart, thyroxin has adrenalin effect, causing the heart to beat faster, and with it a feeling of excitement and anxiety, which is not very well tolerated. However, many side effects can be eliminated if the combined thyroxin and beta-blockers. Beta blockers inhibit the receptors through which affects heart thyroxine thus they prevent the adverse effect on thyroxin heart rhythm normalizes and reduce expression of side effects of some other thyroxine.
Many believe that the thyroxine may irreversibly suppress the function of their own thyroid, but studies have shown that even large doses of 3 weeks of reduced secretion own hormones by only 20%, while after four weeks secretion returned to normal.
Thyroxine advantages: high availability and efficiency. Thyroxine disadvantages: a large enough number of side effects, but many of them can be prevented.
Start receiving thyroxine 50 micrograms per day, 2 times per day (25 micrograms) in the first half of the day. In the morning take 25 mg of metoprolol (a beta-blocker that eliminates heart overload and heart rate), if the pulse rate after lunch above 70 bpm. per minute at rest, take another 25 mg of metoprolol.
Gradually increase the dose to 150-300 mg per day, 3 times a day until 18:00. Increase daily dose of metoprolol to 100 mg (2 times daily 50 mg). Metoprolol dosage is adjusted individually, so that the heart rate at rest was 60-70 bpm. in a minute.
Keep track of heart rate when at rest heart rate above 80 – increase the dose of metoprolol 25 mg if heart rate at rest below 60 beats per minute, reduce the dose of metoprolol 25 mg.
Keep an eye on blood pressure, it should not be higher than 140/90 mm Hg. Art. Metoprolol can reduce blood pressure.
Course Duration 4-7 weeks.
Do not stop taking thyroxine sharply start to reduce the dose for 2 weeks before the end of the cycle, continue to gradually decline to complete abolition.
If you have a diarrhea – included in the course loperamide 1-2 capsules per day.
The minimum interval after the end of 3-4 weeks.
If you have weight in the region of the heart is better to add Asparkam addition to metoprolol. 4-6 tablets per day, divided into 2-3 doses after meals. It is also completely superfluous to improve heart drug Riboxinum. 2-4 times per tablet, 2-3 times a day. Riboxinum improve the energy balance of the myocardium, and Asparkam become a source of potassium and magnesium, necessary for the maintenance of normal heart rhythm.
Course clenbuterol + thyroxine yohimbine
This combination is used in fat burners from CYX3 AxioLabs , and is one of the most powerful. You can save considerably if you take active substances separately. The high efficiency of the complex due to the fact that thyroxine (or triiodothyronine) is able to not only accelerate your own metabolism and start burning fat, but also to enhance the sensitivity of adrenergic receptors , which act through Clenbuterol and yohimbine.
One unit (. U) adopted the following combination of starting materials:
Clenbuterol – 40 mcg
Thyroxine – 25 mkg
Yohimbine – 5 mg (available in sports supply stores)
Dosage is a multiple of said manufactured tablet form drugs. The complex can be excluded yohimbine if you can not buy it, at the same dosage and mode of reception of the remaining 2 drugs be the same again.
Recommended course:
Day 1-3: 1 unit.
Day 4-6: 1.5 units.
Day 7-9: 1 unit. morning 1 unit. after lunch
Day 10-12: 1.5 units.
Day 13-15: 1 unit.
Day 16-19: 0.5 units.
Day 20-21: 0, 25 units.
In the next three weeks it is recommended to give your body a rest, after which the course can be repeated. All the material is recommended to take 30 minutes before breakfast, drinking plain water.
In case of fever it is recommended intake of 1-2 mg of ketotifen in the afternoon. To protect the heart and reduce heart rate must be used beta blockers (metoprolol 50 mg 2 times a day).
This product is available in the following variations:
Proviron (active ingredient – Mesterolone) – hormonal drug with moderate androgenic activity and significantly enhances erectile function. Proviron is often used in bodybuilding during the course of anabolic steroids for various tasks.
Among the well-known manufacturers mesterolone – Schering different company offices (Proviron in the form of tablets of 25 mg), the Moldovan company Balkan Pharmaceuticals ( Provimed, 50 mg tablets ) and some others.
He is a weak inhibitor of aromatase, t. E. Prevents the conversion of steroids to estrogen in the body. According to numerous reports of athletes, in practice Proviron does not prevent gynecomastia , water retention, fat deposition on the female type and other estrogen side effects.
Almost no effect on the body’s own production of testosterone (in large doses can suppress), but increases the concentration of free testosterone in the blood, due to the fact that blocks the activity of sex hormone binding globulin. These properties make it an attractive means Proviron during the course.
Often used as part of post-cycle therapy , although expediency is questionable, since the ability to restore the secretion of endogenous testosterone it does not have.
How to take Proviron during the course
A typical daily dosage for men – 50 mg per day, divided into two equal reception, preferably after the meal. It is considered an acceptable dosage to 100 mg of Proviron per day. Receiving higher doses may cause Proviron® effects contrary to that expected. During prolonged erection, which is often quite painful and uncomfortable, the dosage should be reduced or canceled his reception at all.
Given that the drug increases libido and enhances the potency in men, its use is justified on a course of drugs that lower libido (such as Deca-Dick in the application of nandrolone or Tren-Dick of trenbolone ).
Also, Proviron is often used in bodybuilding in precompetitive preparation for increasing the hardness of muscles and giving it a bump. Is the favorite drug of the Western film actors to give the outward appearance of muscularity, afraid to use heavier steroid “artillery”. It is also used by women to give bodibildershami muscle density, but their dosages should not exceed 25 mg per day of not more than four weeks to eliminate the phenomenon of masculinization . While professional bodybuilders do not adhere to these standards.
The medical use of
“It improves the quality and increases the sperm count. Compensates for lack of production of male sex hormones (androgens), providing a stimulating effect on the development of male reproductive organs and secondary sexual characteristics, it improves libido and potency, showing anabolic properties to stimulate erythropoiesis. How to use: Inside, not liquid, 25 mg 1-3 times per day.
Side effects
It is not toxic to the liver in moderate doses, which makes it safe during a course of reception for several weeks. It suppresses the axis hypothalamus-pituitary-testes . Taking into account the chemical nature and similarity to dihydrotestosterone, possible side effects such as prostate hypertrophy and male pattern baldness of the scalp.
for periodic prostate examination is recommended for prophylaxis. Caution After the application of hormonal substances that are part of the drug Proviron, very rarely observed the formation of benign and even more rarely – malignant liver tumors. In some cases, intra-abdominal bleeding caused by such tumors, posed a threat to life. If a man who uses Proviron, there is severe pain in the upper abdomen, enlargement of the liver or there are signs of intra-abdominal bleeding in the differential diagnosis should take into account the probability of having a liver tumor
The weakening of the AU action
Many authors, for example, A. Vasilenko, and others point to the use of Proviron and anabolic steroids (AS) of the same receptors that supposedly reduces the effect of the latter. For the first time, this information came from Dan Duchaine’s Underground Steroid Handbook II. However, the pharmacokinetics of elementary knowledge can deny it. Firstly, the antiestrogen is rapidly destroyed in the muscles to inactive metabolites. Secondly, due to the high affinity binding proteins (SHBG) drug can increase the concentration of free speakers, which increases the effectiveness of the course.
Legal status
Proviron is available for sale in Ukraine.
Included in the “list of potent substances for the purposes of Article 234 and other articles of the Criminal Code of the Russian Federation.” When it is detected, you in the amount of more than 15 tabs. (2.5 gram tablet form) criminal responsibility. When determining the weight law enforcement recorded including the weight of the filler (starch, TiO2 and other related substances). In some cases, weighting occurs with packaging.
Tamoxifen – this means that blocks estrogen receptors, but does not prevent the formation of estrogens. Tamoxifen is more conducive to the restoration of natural testosterone as well as a way to directly affect the pituitary gland. Among the shortcomings – slightly reduces the anabolic activity of steroid agents. It is used only during the PBC .
Proviron® increases the concentration of androgens by binding to SHBG, thus increasing the efficiency rate. Proviron However, as has been shown in studies, is not conducive to restore testosterone secretion, unlike tamoxifen. Repeatedly performed tests of hormone levels have shown that the anti-estrogen effect on the course of Proviron hardly manifested.
Considering the advantages and disadvantages of both drugs, the best course of steroids is constructed as follows (actual for flavoring speakers only):
Starting from 2 weeks of the course Proviron administered at a dose of 50 mg per day. Further, to control the level of estrogen to be applied inhibitors of aromatase .
Immediately after completion of the course, stops Proviron reception and after elimination of steroids from the body appointed by tamoxifen for 2-3 weeks at a dose of 10-20 mg per day.
This product is available in the following variations:
Letrozole (FEMARA®) also refers to non-specific competitive inhibitors of aromatase. The chemical structure is benzgidrintriazola derivative 4, 4 ‘- [(1 H-1,2,4-triazo-1-yl-methylene) -dibenzonitril. Aromatase inhibitors such as letrozole act by competitive binding subunit of the enzyme – a gene of cytochrome P-450, the drug prevents the conversion of androgens to estrogens in adipose tissue, liver, skeletal muscle and decreases the concentration of the latter in the systemic circulation at 75-95% without significantly affecting synthesis in the adrenal corticosteroids and aldosterone, and thyroid hormones. Letrozole, according to different authors, blocks estrogen receptors in 50-75% of patients. Compared with anastrozole more pronounced (up to 98.8%) blocks the activity of cytochrome P-450 aromatase and significantly reduces the level of estrogen (estradiol, estrone, and estrone sulfate), however, the clinical significance of these data is uncertain.
The drug is available in tablets of 2.5 mg. For letrozole typical dose-response effect, so the dosage regimen should be clearly calculated. Applied per os is usually one tablet 1 time per day regardless of the meal, and then rapidly and completely absorbed in the digestive tract. The extent of absorption is independent of food intake. The equilibrium concentration in plasma is achieved in an average of 4 (2 to 6) weeks of application. The drug does not possess cumulative properties. Since blood plasma proteins, mainly albumin, binds about 60% of letrozole. And it penetrates into erythrocytes, where its concentration reaches 80% of the level in the blood. Letrozole is rapidly and uniformly distributed in the tissues. Metabolized preparation involving isozymes of cytochrome P-450 with a pharmacologically inactive metabolite carbinol (methanol-4,4′-bis-benzonitrile) and its ketone analog. The main route of elimination of letrozole from the body – through the urinary system. Not less than 75% of the administered dose excreted as glucuronide metabolite carbinol, and about 6% – as letrozole unaltered.
When initially expressed existing hepatic dysfunction (elevated liver transaminases), the drug should not be administered. Side effects usually are mild or moderate and similar to those in receipt of anastrozole. Also, 0.6-2% of the women taking the drug, there are bloody vaginal discharge, 1.7% – Leucorrhœa and sweating (1.1%), in a small part of the cases – shortness of breath; thrombophlebitis (0.6%) may develop. It should be noted that uncontrolled receiving letrozole bodybuilders often leads to coordination and promotes the dispersal of the violation.
Nonsteroidal aromatase blocker is a third generation vorozole. Compared with letrozole, it possesses almost identical influence on the levels of estrogen in the blood, but after 3 months after the beginning of reception resulted in a statistically significant increase in breast bone resorption markers in the blood serum of cancer patients. Moreover, 30% of women in the range from 1 to 6 months to three years and a significant reduction in recorded bone density. The most unfavorable of the side effects of this drug is set elevated levels of estrogen in the blood in excess of their reduction under the influence of aromatase blocking. It became clear that these changes are correlated with higher levels of bone resorption markers (Dowsett et. Al., 1999). In a small study in healthy menstruating women volunteers it was shown that vorozole a considerable (more than 74%) proportion of cases leads to the formation of ovarian cysts, ovarian hyperstimulation with pain and increased fluid secretion in Douglas space (Goss et. Al., 2004). So far, randomized trials of the effect of long-term use of this drug on the effectiveness of treatment and the incidence of osteoporosis is not carried out. Known data indicate the inadmissibility of the use of the drug in premenopausal women. The sports pharmacology it is also currently little used.
Representative steroidal aromatase ingbitorov third generation is exemestane, which, entering into covalent interaction with aromatase during the first cycle of oxidation leads to an effective selective irreversible inactivation of the enzyme reduces and estrogen synthesis in the body by 97%. Like anastrazole and letrozole, it is well tolerated by patients. Produced for receiving per os in form of tablets of 25 mg, and the daily dose is in the treatment of metastatic breast cancer in postmenopausal women. Exemestane, which is approved in the USA and is used as a drug in the oncology first-line endocrine therapy for breast cancer after receiving Imre class of drugs so far in the clinical setting has not been studied. However, it found that with respect to the process of accumulation and the extent of aromatization of estrogens it has an activity higher than tamoxifen, but less high than anastrozole (AS TO comparative study, 2002).
Clinical trials have shown that the metastatic breast cancer exemestane more pronounced compared to tamoxifen, slow disease progression, but does not affect the process of metastasis. Randomized MA-17, Research ATAS, IES showed that it differs from the spectrum of toxicity of non-steroidal aromatase inhibitor, but the therapeutic value of this data has not been studied. The drug is subjectively very well tolerated; the most common side effects are hot flushes (19%) and nausea (21%). According to the severity of impact on the development of osteoporosis and the incidence of pathological fractures in patients treated with exemestane, letrozole is not inferior. The risk of pathological fractures compared with the control group (placebo) for exemestane is increased by 60%! Arthralgia accompany the drug in 4.5% of cases, which is higher than that of tamoxifen (3.6%). However, the risk of endometrial cancer, as well as arterial and venous thrombosis significantly lower for exemestane (and also letrozole) than tamoxifen. The frequency of appearance of dryness and itching of the urogenital region when receiving exemestane above, and vaginal discharge – lower than tamoxifen.
Action exemestane on mental ability tests in the above MA-17, ATAS, the IES has not been studied. However, all taking anti-estrogen drugs, you should think about the fact that a lack of endogenous estrogen, even against the background replacement therapy significantly increases the risk of developing dementia in the future.
For the latest irreversible steroidal aromatase inhibitors character refers Ergo-pharm 6-OXO – structural analogue first generation drugs (3,6,17-androstentrion). Its action is similar to formestanom, but the effect on the increase in the level of testosterone in the blood expressed twice as strong. Efficiency for the clinic it has not yet been investigated. It is used in high doses the drug once a day in cycles of 4-6 weeks.
By aromatase inhibitors relates and the newly synthesized corporation MPR substance the T-Bomb II of , having the effect of a second messenger. T-Bomb II, due to the patented mechanism Optimone 5®, by activating the secretion of luteinizing hormone and simultaneously blocking SHBG (Sex Hormon Binding Globulin) – protein binding testosterone – and irreversible inactivation of aromatase, increases endogenous testosterone levels in the body 400%. The resulting substance T-Bomb II contains, besides SHBG, fatty acids, in particular, linoleic, linolenic, stearic and oleic. In addition, it comprises the amino acids glycine and L-arginine, Tribulus terrestris extract (Tr. Terrestris), other plant components, and mineral supplements in the form of magnesium oxide, zinc aspartate and copper gluconate. The mechanism of blocking aromatase, pharmacodynamics and pharmacokinetics of the substance is hardly explored, and preclinical and clinical trials to date, not finished.
On the pharmacological market for weight-lifters available product krizin (5,7-digidroksiflavon) that bodybuilders used in very high doses. It also has antiaromataznymi properties and is available in two forms – MRM-Chrysin, containing 500 mg per capsule of pure krizina and SciFit-Chrysin ES, containing half of the active substance. Descriptions of the side effects of the developers did not cause, but one should remember that all drugs and substances that have antiaromataznym action, can cause substantial harm to the body of an athlete and refer to the list of prohibited substances and methods.
This product is available in the following variations:
Fluoxymesterone (Halotestin) – tableted anabolic steroid with a pronounced androgenic and anabolic effect relatively weak. It is mainly used to improve athletic performance, muscle density and aggression, without increasing the total body weight. The mean specific activity of Halotestin is used mainly strength athletes who do not want to increase the weight class, as well as in boxing and other combat sports, directly in front of the competition. Fluoxymesterone is highly toxic to the liver. The exact mechanism of action has not yet been studied, it is assumed non-receptor effect on the muscles.
Trademarks
International name: fluoxymesterone (Fluoxymesterone)
Synonyms:
Halotest 300 from the Balkans (Moldova)
Androyd Brown United States.
Halotestin Upjohn
Husteron-Tubbs Major US.
Ora-Testru Squibb Mark US
Ultandren Ciba Grobbritanied
The steroid profile
Anabolic activity- 1900% of testosterone
Androgenic activity- 850% of the testosterone (very high)
Aromatization(conversion to estrogen ) – No
The suppression of the hypothalamic-pituitary-testes- expressed
Toxicity to the liver – very high
A method for receiving – orally (tablets)
Duration – 6-9 hours
Detection time – 2 months
Pharmacological Properties and Effects
Initially used as fluoxymesterone agent with pronounced androgenic properties used in the treatment of male hypogonadism and delayed puberty in males for the treatment of breast cancer in women. Nowadays medicine refuse to use it. Halotestin is about five times more powerful than methyltestosterone .
Halotestin (Fluoxymesterone) is similar in structure to methyltestosterone. It was developed by modification of testosterone in three positions: 17-alpha-methyl group of 11-beta-hydroxy and 9-flyuorogruppa.
The first chemical modification allows to extend the half-life of the drug when administered orally and neutralize destructive first-pass effect through the liver, while maintaining the maximum concentration of active substance in the blood.
The second modification is aimed at preventing the enzymatic conversion of the molecule by attaching it to the aromatic ring, in other words, the drug is not converted to estrogens. It is supposed to block the ability of estrogen and prolactin receptors, which excludes the risk of gynecomastia, edema and fat deposition on the female type.
The latter group determines the name of the drug (fluoxymesterone) and is aimed at improving the androgenic activity of the drug (5a facilitates a reduction in the position, which leads to the formation of digitrotestosterona). It is the active form of the drug circulating in the blood normally in small quantities, greatly exceeds the activity of testosterone and can bind tightly to androgen receptors in cells of organs and muscle tissue.
It was also noted that the drug improves aerobic performance of athletes in track and field. It is associated with the ability to stimulate erythropoiesis, hemoglobin synthesis. At the same time increasing the number of red blood cells is able to more efficiently transport oxygen to the cells.
Fluoxymesterone may be used to burn fat, as it was shown that the drug enhances oksislenie fatty acids in the fast-twitch muscle fibers. Although for this purpose there is also a safe and effective anabolic agent, particularly winstrol, testosterone, oxandrolone.
Side effects
With the increased speed of the formation of DHT from testosterone is associated hypertrophy and hyperplasia of the prostate, the development of BPH and may increase the likelihood of developing cancer. Relatively easy ability of the drug to move into dihydrotestosterone may further have adverse health effects in terms of its long-term use. Fluoxymesterone is judged as a drug that exceeds 19 in the testosterone anabolic capacity, 8.5 times and androgenic properties. Information about the activity of the drug was obtained experimentally.
Halotestin is toxic to the liver. Athletes use the drug frequently report an increase in morbidity and organ. Studies have shown that the drug will certainly lead to increased levels of liver enzymes, indicating that the steady process of increasing degradation of liver cells under the influence of fluoxymesterone. This fact is confirmed by literary sources.
Cycle
The optimal dose of Halotestin is 10mg / day is recommended not to exceed the dose of 20 mg / day. In addition, long-term use Halotestin (6 weeks) may harm sexual function. Based on the ratio of benefits and harms, holding Halotestin most appropriate cycle just before the competition, in order to obtain two basic effects to enhance the physical strength and aggression.
Fluoxymesterone is virtually muscle growth. Drug combination with other anabolic agents also have special advantages.
Halotestin® available in tablets of 5 and 10 mg (1 mg less). The drug is a rare, but has now become available from the Moldovan Halotest 300 Balkan pharmaceuticals.
This product is available in the following variations:
Clomid (clomiphene) or Nolvadex (tamoxifen), which is better?
In this article we will try to resolve doubts about the choice between the two drugs, as well as find the differences: Clomid and Nolvadex.
Clomiphene citrate (available in pharmacies under the brand names Clomid, Clomid) and tamoxifen (brand name Nolvadex) is antiestrogen belonging to the same group trifeniletilenov. They are structurally similar and are classified as selective modulators of estrogen receptors with mixed agonistic and antagonistic properties. This means that in certain tissue, they block the action of estrogen by binding to a receptor, while in other tissues could act as a real estrogen receptors activating. In men, both drugs act as anti-estrogens in their ability to interfere with estrogen negative feedback on the hypothalamus and stimulate the increased production of GnRH (gonadotropin-releasing hormone). This will result in increased production of luteinizing hormone by the pituitary gland, which in turn can increase the production of testosterone by the testes. This makes both drugs, but for some reason bodybuilders continue to think that only good for Clomid testosterone stimulation.
Studies conducted in the late ’70s in the University of Ghent in Belgium make clear the advantages of Nolvadex over Clomid to increase testosterone levels . Researchers have looked at the effect of Nolvadex and Clomid on the endocrine system healthy men, as well as those who have suffered a small amount of spermatozoids (oligospermia). also found that Nolvadex when used for 10 days at a dosage of 20mg per day increased testosterone in the serum 142% of the initial level that was comparable with the effect of Clomid 150mg per day over the same period of time (an increase in testosterone levels were slightly but not significantly greater with Clomid). We must remember that this is the effect of three 50mg tablets of Clomid. At about the same price 50mg Clomid and 20mg Nolvadex we can already see a difference in relation to the price / benefit result in Nolvadex.
Clomid (clomiphene) or Nolvadex (tamoxifen): difference
Clomid (Clomid) acts on the estrogen receptors in the pituitary and ovaries. By linking estrogen receptors in the pituitary gland, Clomid breaks a negative feedback mechanism, ie, if usually estrogen, acting on the pituitary gland, reduce the production of FSH and LH , when taking Clomid does not happen. Directly on blood levels of estrogen Clomid does not work.
Nolvadex (tamoxifen) also has no effect on the blood level of estrogens because its mechanism of action is also reduced to the estrogen receptor blockade, including the pituitary gland. However, Clomid is a more selective (selective) blocker and Nolvadex – less selective. If Clomid binds to estrogen receptors in the pituitary and preferably testes Nolvadex then contacting them almost in the entire organism. The exception is the bone where clomid and tamoxifen contrary to activate estrogen receptors.
Thus, Clomid acts as an estrogen antagonist and eliminates their inhibitory effect on the hypothalamus and pituitary gland, contributing to a more rapid recovery of their functions. Nolvadex blocks the receptors in almost all tissues and helps to ensure that the body began to rebuild its own testosterone. Importantly, Nolvadex capable of blocking estrogen receptors in the pituitary less than Clomid.
Clomiphene and tamoxifen did not affect the metabolism of estrogenic hormones, so the intake of estrogens these means continue to erode the liver enzymes, and do not accumulate in the body.
Tamoxifen has drawbacks: quite toxic (sometimes it manifests itself loss of appetite and nausea, increased risk of thrombosis). Tamoxifen increases the number of receptors of progesterone , so it can not be used, if the rate is based on progestin drugs ( nandrolone, trenbolone). In this case, you should use clomiphene.
The general conclusion
Nolvadex (tamoxifen) is preferred option compared to Clomid (clomiphene) because:
Despite minimal effect on the pituitary gland, Tamoxifen has the same ability to restore the level of testosterone as Clomid and
Tamoxifen blocks the effects of estrogen in the body, including the pituitary and hypothalamus, which means that it will not only contribute to the restoration of testosterone secretion, but also prevent fluid retention in the body.
Tamoxifen significantly cheaper than Clomid
Tamoxifen reduces the level of cholesterol, which is important in the use of steroids
Increase the concentration of estrogen in some times
Causes of visual impairment with prolonged use of
How and when to take Nolvadex (tamoxifen)
The most efficient in the cycle of use of aromatase inhibitors, among which the most popular Proviron, because this drug has no adverse effect on the secretion of growth hormone and anabolic hormone increases the concentration in the blood by inhibiting the aromatization. In the last week of the cycle , and 2 weeks after tamoxifen should be used as the main component of PCT If no Proviron, Nolvadex has to start receiving 2 week steroid cycle, and ends 2-3 weeks after the end of the cycle, the average dose of 10-20 mg per day. I would like to pay special attention to the common misconception that anti-estrogens is recommended to drink after a cycle. Estrogen level rises at the end of the first week of the cycle, so from that moment you need to start the reception!
If used anabolic drugs, which are not subject to aromatization necessity disappears aromatase inhibitors, whereas tamoxifen activated only at the end of the cycle. Read more best cycles of steroids .
Turinabol (Oral) (chemical 4-hlorodegidrometiltestosteron.) – Anabolic steroid, which is similar in chemical structure and effects to methandrostenolone. The word “screaming” in the name means that the anabolic agent is administered orally (inside). Unlike methandrostenolone is Turinabol that contains an additional chlorine atom in the fourth carbon atom. The drug first developed by the German pharmaceutical company Jenapharm and patented in 1961.
To achieve success in the Olympic Games, since the 60s of the last century, Eastern Germany has developed a number of highly effective anabolic steroids, including drug oralturinabol. The developers describe it as a combined version of methandrostenolone and Oxandrolone with moderate anabolic effect (comparable to testosterone) and low incidence of side effects. Creator is Albert Stachowiak.
Description
The preparation can be characterized as Methandrostenolone without effect of fluid retention in the body.
This delayed acting steroid. During the cycle Turinabol weight, power and performance relief progressing very slowly, but the results are better with the words of the athletes.
Another distinguishing feature of the product – no estrogenic effects (because is not exposed to flavoring, by adding a chlorine atom in the molecule), ie side effects such as fluid accumulation, gynecomastia, etc. almost never occur. Although there are reviews, which reported on the development of gynecomastia, which is the development of the mechanism remains unclear. The most likely reason – the presence in the methyltestosterone , which is related to the synthesis features.
Also, it was determined that the concentration decreases SHBG, thus increasing the level of free testosterone in the blood. There is evidence that Turinabol reduces the risk of blood clots in blood vessels and heart.
Cycle
During the preparation of the Olympic Games in an optimal dose was chosen, which caused minimal adverse effektov– 20-40 mg per day, divided into three stages , but bodybuilders often neglect these figures, bringing the dose to 100-150 mg per day .
The preparation can be applied both in the recruitment of muscle mass, and drying. Turinabol cycle need not include anti-estrogens and gonadotropin (if not exceeds 6-8 weeks), but PKT carried blockers estrogen receptor ( tamoxifen ). Monokurs Turinabol is one of the easiest and safest in bodybuilding, so it is often recommended to beginners. For the first course is considered to be the optimal dose of 40 mg / day for 6 weeks. This allows you to get impressive results, both in terms of growth of quality muscle mass, as well as in the progress of speed-strength results.
For a set of muscle mass is the best combined cycle Turinabol (20 mg daily) + testosterone enanthate 250 mg per week (or + Sustanon ). The average duration of 6 weeks. First enanthate is canceled, and a week later Turinabol.
Athletes who are not interested in a set of weights and seek to increase speed and endurance (boxers, wrestlers, runners, etc.) recommended a lower dose – 10-20 mg per day. However, it should be noted that in recent years oralturinabol become problematic in terms of anti-doping steroid, as recently discovered (2012), long-lived metabolites are determined in six – eight months. Great contribution to such an incredibly long period of detection made by the latest developments in the field of gas chromatography-mass spectrometry.
Turinabol 17 is alkylated anabolic steroid, which enables oral administration, but creates a toxic effect on the liver, comparable to methandrostenolone. In general, side effects are rare and are most commonly associated with the excess of the cycle duration and high doses. This drug strongly inhibits the secretion of testosterone. Can erectile dysfunction after the cancellation, there have been cases of premature ejaculation.
Violations of the Liver: cholestatic jaundice, necrosis of hepatocytes with liver failure, liver cancer. From the biochemical parameters determined by increased levels of bilirubin, alkaline phosphatase and transaminases. Cholestatic jaundice may occur after 6 months or more (a toxic origin) and manifested stasis in the bile capillaries with hyperbilirubinemia and increased activity of alkaline phosphatase. When applying for several years may increase the frequency of liver cancer.
An official report of a carcinogenic effect was observed for 5 years of use Turinabol in relatively high doses.
Endocrine disorders: Turanabol less than other drugs in men can cause: inhibition of spermatogenesis and impotence (second decrease the secretion of gonadotropins and testosterone with testicular atrophy and oligospermia); prostatic hypertrophy (mainly in the elderly); epididymitis; priapism. The boys may experience precocious puberty, frequent erections, increase the risk of suspension.
Metabolic disorders: decreased glucose tolerance; increase the level of low-density lipoproteins (LDL); accelerated clearance of creatinine; elevated levels of creatine phosphokinase; swelling relatively rarely observed because of the low delay of sodium and water; delay potassium, calcium and phosphorus. Patients with prolonged bed rest can develop hypercalcemia .
Other : at puberty may prematurely closed epiphyseal bone areas with growth retardation.
In women, the drug can cause rare: decreased secretion of gonadotropins; phenomena virilization (acne, hirsutism, deepening of voice, increase libido , menstrual disorders , hypertrophy of the clitoris, development of muscles). Pregnant women can develop virilization of the female fetus. The frequency of these side effects have Turanabol low.
Boldenone Undecylenate (also known under the trade name Equipoise is (Equipoise) , Boldabol , Boldebal , Boldesten , Ganabol ) – an anabolic steroid developed for veterinary use. The drug was created as version methandrostenolone long-acting, but the result was a steroid, which has a completely different properties, despite the similarity of chemical molecules. Boldenone Dianabol is a molecule which is devoid of 17-alpha-methyl group (this part of the molecule Dianabol allows passage through the liver without being destroyed). If we compare the performance of boldenone undecylenate and Dianabol, the results obtained in the set weight and increasing strength is almost the same.
Equipoise is a chemical molecule of testosterone , which has a double bond between the 1 and 2 carbon atoms. This modification is made in the same boldenone potent as testosterone, for anabolic properties, whereas androgenic properties of the drug expressed in two times weaker. However, practice shows that Equipoise allows you to get lower results than an equivalent amount of testosterone.
Boldenone Undecylenate is often compared to nandrolone , obviously, it is associated with the book Dan Duchaine, which the author draws parallels between the two drugs, noting, however, that a stronger anabolic boldenone. In fact boldenone and nandrolone are different. Nandrolone is a progestin and a 19-nor steroid whereas Boldenone is closer to testosterone. Dan Duchaine later changed his mind with regard to the similarity of drugs, but on the forums, you can still find messages that are not recommended to combine Boldenone and nandrolone because of the similarities. Dan Duchaine also writes that Equipoise is more suitable for the relief and venous prorisovannosti than for a set of muscle mass.
New forms of preparation: boldenone acetate and boldenone propionate have similar effects, the difference lies only in the duration.
Athletes taking boldenone often report a slow but high-quality set of muscle mass. It is believed that the slow effect of the drug is associated with a long ester (undecylenate), which is attached to a molecule Equipoise. Undecylenate longer than 1 atom than the decanoate. For this reason, we can expect a slow and prolonged muscle growth while Equipoise rate than during the course of Nandrolone. This also determines the duration of the course – up to 10 weeks. As Deka, Equipoise for a long time in the body is determined, what should remember competing athletes.
The drug increases the power rates and significantly increases appetite.
Equipoise is largely stimulates the formation of blood. Increased erythrocyte content improves the delivery of oxygen to the muscles. This makes this an attractive steroid for athletes.
Boldenone – side effects
The double bond between the 1 and 2 carbon atom is responsible for many of the properties Ekvipoyz’a. First, it inhibits aromatization process (conversion to estrogen ) preparation. If we compare with testosterone, boldenone is the conversion rate of two times lower. Athletes almost never noted side effects boldenone related to estrogen ( gynecomastia , edema, high blood pressure), even if the dose up to 1 g per week. This means that during the course not necessary Equipoise receiving antiestrogens.
Low androgenic activity allows the use of Equipoise women. The phenomena of virilization occur rarely, compared with other drugs. Boldenone – this is one of the few injectable drugs that can be used in the women’s bodybuilding with the lowest risk of side effects.
The same double bond provides resistance Equipoise to the enzyme 5-alpha-reductase. This enzyme converts a small amount of boldenone in digidroboldenon, which is a potent androgen (7 times more powerful than testosterone). Therefore, the drug is virtually androgenic side-effects such as alopecia, acne , prostate hypertrophy, et al., as well as to a lesser extent inhibits the production of testosterone in the body.
Boldenone rate (dosage)
The optimal dose of boldenone is 400-800 mg once a week. Lower dosage is usually ineffective, large dosage does not lead to better results, but increases the risk of side effects.
boldenone course lasts 8-10 weeks.
Equipoise is well combined with other steroids: Winstroland Anavar – drying course, testosterone and trenbolone – course set weight (in this case the duration of the course is reduced to 6 weeks as a combination of largely suppresses testosterone production, but also need to take anti-estrogens during course.
Consult with an expert before you start Equipoise course.
2 weeks after the end of the course spend PCTand begin taking testosterone boosters for a month to restore natural testosterone.
For maximum efficiency, take a course package for a set of muscle massand follow the diet for a set of muscle mass .
This is one of the best courses for beginners. Equipoise reduces testosterone dosage without compromising anabolic effect, thereby reducing the internal conversion of steroids into estrogens and androgenic activity rate. Tamoxifen is almost completely eliminates the possibility of estrogen side effects.
Week 1 – 8: Equipoise 800mg / week
Week 1 – 8: Testosterone enanthate 500mg / ml
Week 1-10: Anastrozole Letrozole or on the results of the analysis on estradiol
Androgel – drug 1% of testosterone in gel form for application to the skin, designed for replacement therapy. Currently, testosterone gel is one of the most commonly prescribed drugs prescribed to patients with low levels of testosterone (hypogonadism). Androgel is manufactured by Solvay Pharmaceuticals. Androgel increases testosterone levels in the blood, penetrating through the skin.
Androgel analogue also present on the market – the dough (Testim), Which is available in tubes by Auxilium ] In fact, there are no pharmacological differences between the two drugs.
Most famous Androgel received as a result of the scandal erupted in the United States a few years ago when it was revealed that the famous coach Trevor Graham said that several popular athletes use testosterone gel to improve athletic performance. Later it became clear that athletes are not even aware that using hormonal drug, mistakenly believing that rubbed into the skin cream harmless.
Androgel testosterone gels and others have a very high cost.
In bodybuilding is necessary to create a high concentration of anabolic hormonesin the blood that can not be achieved through the skin. The picture on the right you can see that increasing the dose of the drug Androgel testosterone leads to an increase in the concentration of about 150 units. Thus, to create the required concentration will require about 50 grams of gel, which significantly increases the expense of the preparation (economically very costly), the application makes it extremely inconvenient. It is necessary to cover a large area of skin preparation, and even in this case, the gel layer will be so thick that most of the testosterone gel to remain on clothes.
Thus it becomes clear testosterone gel – Androgel is inappropriate to use in bodybuilding.
Testosterone cypionate – this is one of the longest ester of testosterone available today. Its half-life in the body is approximately 15 to 16 days ( half-life 6.8 days). The drug is available in the form of an oily solution. Because it operates over such a long period of time, it can cause water retention to a greater extent than other anabolic steroids. Most often, it is used in the combined set of cycles to muscle mass.
In the body, testosterone cypionate acts like the natural hormone testosterone – a male sex hormone that is responsible for many of the physical and emotional quality of men. It causes deepening of the voice, sex drive, aggression and muscle growth. Testosterone operates through anabolic receptors, causing the muscle to retain more nitrogen, which, in turn, are the muscle proteins.
Testosterone cypionate disadvantage is that it is flavored, or in other words is converted into estrogen . When in the male body produces too much estrogen begin to appear feminine traits: gynecomastia , water retention, fat deposition on the female type, and there is a decrease in sexual desire and testicular atrophy . Most of the undesirable effects can be avoided if you use the drug correctly.
Description
The rate of elimination from the body is comparable with enanthate
Especially prevalent testosterone cypionate in the United States. Although Testosterone enanthate is produced at an increasing rate around the world, cypionate is produced mainly in the United States. It is therefore not surprising that American athletes often use it it in their practice.
Many argue that the American athletes preferences have less to do with the greater availability of cypionate, compared with other esters, as with his great anabolic effect. Disadvantages of the drug, including fluid retention can be eliminated by antiestrogens .
If we compare testosterone cypionate or enanthate objectively, we can conclude that these two steroids are interchangeable, and cypionate is essentially no better. Both long-acting oil-based injection administered. This allows you to maintain a high level of testosterone for about two weeks. Enanthate may be more preferable from the viewpoint of free testosterone release form, as in the air on one carbon atom less (duration of action of testosterone esters is greater than the longer chain ester). Despite the stormy arguments on forums, in practice, the difference is very small, so the choice may be dictated by the availability of more than pharmacological properties.
Effects
As with all injectable form of testosterone cypionate is a significant increase in muscle mass and strength during a cycle. Because testosterone is easily converted into estrogen, about 30% of the mass is accounted for fluid that is lost quickly after the cycle.
For this reason, testosterone cypionate is not very suitable for the cycle. Excess estrogen levels caused by this drug can lead fairly quickly to the development of gynecomastia, which is manifested as pain, swelling or induration at the nipples. To prevent this, use ancillary drugs ( Nolvadex and Clomid ). Antiestrogens minimize the effects of estrogen, and reduce the action of anabolic steroids in the directional direction. It is best to use aromatase blockers.
Since testosterone is the primary male androgen , we can also expect the development of pronounced androgenic side effects . Their expression is largely related to the rate at which the body converts testosterone into dihydrotestosterone (DHT). This substance is a metabolite of testosterone, which is responsible for the development of certain androgenic effects that are associated with the use of testosterone cypionate. These include: increased secretion of sebum, acne , hair growth on the body and face, as well as male-pattern baldness.
color of hair loss is not expressed at all. Worry about it should first of all those who have a genetic predisposition (the case of baldness in the family). To prevent this side effect, the drug may be used Propecia (Proscar), which blocks the conversion of testosterone to dihydrotestosterone. Propecia significantly reduces the risk of alopecia, and reduces the likelihood of remaining androgenic effects.
Cycle
Despite the fact that the duration of action of the drug is quite large, injections are performed once a week, to keep the concentration constantly high.
The average single dose is 250-500 mg per week, with a view to gaining lean muscle. The drug gives good results during the cycle of “solo”. Experience has shown that higher doses of 800-1000 mg does not lead to better results, but sharply increases the risk of side effects.
As noted above, to block the action of estrogen should be used tamoxifen (10 mg per day, starting from the second week of the cycle, and ending his welcome after 2 weeks after discontinuation of testosterone). A more preferred embodiment: use during the cycle of Proviron. After administration of testosterone Proviron should be replaced by Tamoxifen, to restore the secretion of testosterone. The use of anti-estrogens reduces the accumulation of fluid in the body and suppresses the development of gynecomastia. Be sure to read the article about the PCT .
Combined testosterone cypionate cycle is not much different from the “solo”. The drug is often combined with nandrolone 200 mg per week. Cypionate average dosage of 200 mg per week.
Clenbuterol (Clenbuterol , “Maple”) – a drug that is used in medicine for the treatment of bronchial asthma. In recent years, clenbuterol is widely used in bodybuilding and fitness in relation to its ability to burn fat, so it is often used by athletes for weight loss and drying. Cycles clenbuterol often include thyroxine and ketotifen to accelerate the weight loss process. Clenbuterol is not related to anabolic steroids and belongs to the group of agonists that exert their physiological effect due to excitation of the beta 2-adrenergic receptors, resulting in the sympathetic nervous system is activated and starts lipolysis . To purchase the drug requires a prescription.
Several scientific papers have reported frequent unauthorized inclusion of clenbuterol in the sports supplements for fat burning.
The mechanism of action
It is a beta-2 agonist, clenbuterol acts as a fat burner, binding to beta-receptor type 2 in adipose and muscle tissues of the human body. Once the receptor binds clenbuterol, starts a cascade of biochemical reactions that lead to increased synthesis of cAMP (cyclic adenosine monophosphate). cAMP in turn activates enzymes that mobilize fatty acids from adipocytes (fat tissue cells).
Anabolic and anti-catabolic effect of clenbuterol.
The action of clenbuterol on the beta-2-adrenergic receptors of the presynaptic membrane is enhanced release of noradrenaline and adrenaline, which possess potent fat-burning effect. Clenbuterol increases the basal metabolism by 20-30% from baseline.
Clenbuterol inhibits the activity of lipoprotein lipase, it becomes impossible resulting in the deposition of fat in adipose tissue. Acting beta-2-adrenergic receptors of the central nervous system, the drug enhances the secretion of thyroid hormones – zhiroszhigateli natural organism.
A unique feature of Clenbuterol is that it is not only a powerful fat burner, but also has a strong anti-catabolic effect , protecting muscles from breaking down, which is very important during weight loss and drying in bodybuilding. Studies have shown that anti-catabolic effects of the drug caused by blocking Ca 2+ dependent and ubiquitin-proteasome proteolysis.
The mechanism of action of anabolic clenbuterol through gene expression SRTC2
A study in 2012 (Francesca Wannenes, Loretta Magni) confirms the ability of clenbuterol to block the mechanisms of muscle atrophy. A new study in 2014 showed that β-agonists (catecholamines) released during intense exercise cause CREB-mediated transcription through the activation of its obligate coactivators CRTC2 and Crtc3.
Given the fact that the preparation hardly interacts with beta-1-adrenergic receptors occur expansion and bronchial respiratory relief, as well as a much lower frequency of side effects to the cardiovascular compared with nonselective agonists system, such as ephedrine.
Studies in humans
Study Lee P. 2015 became the first reliable evidence of the effectiveness of beta-agonists in humans. An analogue of the mechanism of action of formoterol ( .beta.2 selective agonist) at a dose of 160 mg/day stimulate anabolism, increased protein synthesis, without causing side effects of the cardiovascular system, while these effects are more pronounced in women.
In addition, in Morten Hostrup (2015) found that the beta-2-agonists terbutaline (10-15 mg/day) causes a statistically significant increase in lean body mass, increases strength and endurance at maximum load on a stationary bike.
The low incidence of adverse events (practice shows that irreversible side effects is almost totally absent) and a wide range of positive effects of clenbuterol make one of the best fat burners bodybuilding.
Some writers (Yuri BOMBEL) argue that large doses of clenbuterol may have catabolic effects, but this is not true, in the absence of any physiological or empirical justification.
Cycle clenbuterol: weight loss or drying
In men, the recommended dose of clenbuterol for drying and losing weight is 120 – 140 micrograms per day. In women, the average dose of clenbuterol for drying and losing weight is 80-100 mg per day. clenbuterol cycle has its subtle features that must be followed strictly in order to avoid side effects.
Duration Clenbuterol is usually 2 weeks, then produced addictive (tolerance receptors) and reduced effectiveness. After that you need to do 2 week break with ketotifen , without a break of no use, and then repeat the cycle; ketotifen without a break should be much larger. Need a break scientifically proved in 1990: desensitization of beta-adrenergic receptors developed by phosphorylation of the receptors, and by other biochemical modifications at the level of second messengers (kinases, G-proteins, and others.). In the update of these structures requires several days.
The duration of the cycle and efficiency of clenbuterol, as has been said, can be increased by the inclusion of ketotifen. Sometimes, to prevent receptor adaptation recommended pulse rate – 2 days of reception, 2 rest days, but this scheme is less efficient.
Do not forget during the cycle to take a sufficient amount of protein, BCAA’s and other blockers, cortisol , it will significantly improve the result. Observe proper diet for weight loss or drying .
In 2010, a study, which revealed a synergistic effect when combined with anabolic steroids, which confirms the desirability of placing on the drug at the end of the AU cycle. Many experts do not recommend to combine the drug with anabolic steroids, because the risk of heart hypertrophy.
Clenbuterol cycle without ketotifen
Day 1: 20 g (0,02mg)
Day 2: 40 mg (0,04mg)
Day 3: 60 ug (0,06mg)
Day 4: 80 g (0,08mg)
Day 5: 100 mg (0.10 mg)
Day 6-12: 120 mg (0.12 mg)
Day 13: 80 mcg (0.08 mg)
Day 14: 40 micrograms (0,04mg)
break
Clenbuterol dose should increase progressively during the first week. The optimal time for receiving clenbuterol – in the morning (not to provoke insomnia, also in the morning the effectiveness of the drug above). By increasing the dosage start to take it in 2 divided doses, morning and afternoon.
Cycle clenbuterol + Ketotifen
Ketotifen – antiallergic agent, with the unique ability to restore the sensitivity of beta-2-adrenergic receptors to clenbuterol. This property has been repeatedly demonstrated in the studies. With ketotifen 10-20 percent can accelerate the process of weight loss and prolong the drying rate of up to 8 weeks. Everything else, ketotifen help eliminate mental agitation, tremor of limbs, insomnia, and heart palpitations.
Day 1: 20 mcg Clenbuterol
Day 2: 40 mcg Clenbuterol
Day 3: 60 mcg Clenbuterol
Day 4: 80 mcg Clenbuterol
Day 5: 100 mcg Clenbuterol + 1 mg ketotifen
Day 6-27: 120 mcg Clenbuterol + 2 mg ketotifen
Day 28: 80 mcg Clenbuterol + 2 mg ketotifen
Day 29: 50 mcg Clenbuterol + 1-2 mg ketotifen
Day 30: 33-35 mcg Clenbuterol + 1 mg ketotifen
at least two weeks interval
Ketotifen is taken at night, clenbuterol – in the morning. Dose distribution is the same as in the previous example.
See main article: The combination with thyroxine and yohimbine
Side effects Clenbuterol
The side effects of clenbuterol are listed by frequency of occurrence:
Palpitations (60%) – is eliminated beta 1-blockers. Take 5 mg of bisoprolol, or metoprolol 50 mg in the morning.
Shivers (20%) – is particularly pronounced in the first day of admission, then gradually fades away. Ketotifen is eliminated.
Sweating (10%)
Insomnia (7%) – ketotifen is eliminated
Anxiety (6%) – ketotifen is eliminated
Increased blood pressure (6%) – eliminated beta 1 blockers. Take 5 mg of bisoprolol, or metoprolol 50 mg in the morning.
Violation of the chair – diarrhea (5%) – as a rule, is observed only in the first days of dosing
Nausea (3%)
Convulsions (with overdose or at the initial stage of the drug)
In individual cases, possible headache, most likely associated with an increase in blood pressure.
As you can see, many of the side effects of clenbuterol can be prevented with ketotifen and bisoprolol (metoprolol). Also, it should be noted that the majority of side effects are particularly pronounced only in the early stages of the cycle, and they subside or disappear completely within a few days.
The book Ostapenko “Anabolic means” there is information that due to the accumulation of polyamines in cells, clenbuterol can cause malignant process and lead to an increase in the internal organs (such as cardiac hypertrophy), which may explain the pronounced protrusion of the anterior abdominal wall in many of today’s athletes . However, these statements do not have a scientific and practical evidence, so they can only be regarded as the author of the guesswork. In addition, it was determined that an increase in abdominal cavity of professional athletes is primarily due to the use of high doses of growth hormone .
It is not recommended to combine clenbuterol and alcohol, as this may enhance nausea and palpitations. Clenbuterol alcohol increase and the load on the cardiovascular system. In addition, alcohol interferes with weight loss and drying. Alcohol destroys muscles.
Drostanolone (trademarks Masteron, Drolban, Metormon, Permastril, etc.) – An anabolic steroid which is produced in the form of ether propionate and enanthate. Masteron has high androgenic activity and a moderate anabolic effect. Masteron does not aromatize in the body (that is not converted into estrogen ), on the other hand is an aromatase inhibitor . Drostanolone is similar in biological action to dihydrotestosterone , as a derivative of the hormone (chemical formula Masteron -. 2a-methyl-dihydro- testosterone propionate). In medicine, Masteron used as a cure for breast cancer in women, but in view of the high probability of virilization is currently little used. The drug is practically not available on the black market in USA.
Drostanolone usually available in ampoules of 50 and 100 mg/ml.
Initially Dromostanolone (shortened to Drostanolone) recognized by trade-name Masteron is definitely an injectable acrylic-centered anabolic steroid, based on Dihydrotestosterone (DHT). It’s an associate of the DHT-produced group of steroids. Additional acknowledged DHT-types contain: some more, and Winstrol, Anadrol Primobolan. Drostanolone (Masteron) is recognized as a reasonable power anabolic steroid with anabolic score: 62 – 130 and reduced androgenic strength: 25 – 40.
Drostanolone Propionate is widely used by athletes in bodybuilding, to preserve muscle mass and strength during a cycle “drying”. Drostanolone is used often runners and athletes who want to keep the weight category (no weight gain).
Biochemistry of Masteron Drostanolone
Masteron is just an altered type of Dihydrotestosterone, in the 2nd (carbon leader) atom having a methyl team. This customization accounts for the power boost that is anabolic. This team causes it to be harder for that 3 that is molecule -hydroxysteroid dehydrogenase to Masteron. This molecule is not generously past in muscle tissues, and it is accountable for degrading any DHT into two metabolites: 3- 3 and Androstanediol – Androstanediol. As a result of this molecule DHT is catabolic in muscle tissues at-all. It’s thought when the molecule 3-hydroxysteroid dehydrogenase was neutralized, DHT might really be considered an anabolic steroid that was really effective. The methyl team inclusion of drostanolone causes it to be imune for this molecule.
Drostanolone is shot in to the physique being an ester (glued to possibly Propionate or Enanthate). Nutrients cleave the ester off in the Masteron particle – . This method triggers prolonged half-life and the steady launch price of the steroid. Propionate includes a halflife of 2.5 days, while Enanthate includes a halflife of 10 days.
Designed utilization of Drostanolone Masteron
Masteron was promoted like a therapy of breastcancer that was female. Drostanolone was progressively eliminated since it pronounced faculties in ladies and since more efficient breastcancer remedies were created.
Masteron popular in bodybuilding, so it does not cause fluid accumulation and has a mild diuretic effect, it helps to improve relief and muscle definition. Drostanolone may be of interest to those athletes who wish to increase the hardness and density of the muscles, usually it is used just before the competition. Drostanolone allows for maximum expressive condition of muscle, it also is due to fat burning effect of the drug. Practice shows that Masteron cycle can reduce fat mass by 5-7% of the original.
Masteron can increase power rates, while maintaining the overall weight and reducing body fat component. This makes it attractive drostanolone in powerlifting. The drug can be used in the diet to lose weight in order to maintain muscle mass and suppression of catabolism.
Ramifications of Drostanolone / Masteron (appealing)
You will find primarily two appealing ramifications of Testosterone:
System improvement (muscle accumulation, weight loss)
The remainder of testosterone results that are appealing that the person may encounter throughout the period that is steroid, contain: Escalation in mineral information and synthesis. Collagen may be the protein-centered building substance for connective cells through the physique (the structures, muscles, cartilage, joints, and bones).
Escalation in degrees of IGF1 and MGF hormones (which additionally market muscle development)
Elevated hemoglobin (red blood-cell count)
Anti- effect of performing being an anti on muscle groups by way -glucocorticoid
Side effects Masteron
Masteron has low anabolic index, which is why he is so good burns fat, at the same time it increases the risk of androgenic side effects: aggression, acne, baldness, prostatic hypertrophy and virilization in women. Once the Olympic Games almost all the gold medals were obtained by the German swim team, it was later proven that athletes have used a derivative of dihydrotestosterone, and apparently it was Masteron. During the interview, a reporter asked, why all athletes a low voice? On this one of them I said that they were there to swim, not to sing.
Masteron does not cause side effects such as fluid retention, high blood pressure increase and has a low toxicity to the liver.
Masteron cycle
Optimal effect is achieved when using the drug dosage of about 400-500 mg per week. A larger increase in dosage does not lead to significantly improved results. Given that has a short chain propionate, drostanolone propionate must be administered 3 times a week (or every other day).
The combination of drostanolone
Due to its high affinity to the androgen receptor of drostanolone and its androgenic properties, it is recommended to combine this medication with steroids such as Winstrol or Oxandrolone . Winstrol® less interacts with androgen receptors to reduce the concentration of sex hormone binding globulin, so the combination will have a pronounced synergistic effect during the drying cycle.
For a set of muscle mass, and is recommended to combine Masteron Testosterone propionate, but in this case largely suppressed production of testosterone. Therefore, the need to use long cycles gonadotropin. Also, it is often advised to combine Masteron and Trenbolone or Boldenone.
Methenolone (more commonly known as Primobolan and Primobol, Nibal) – anabolic steroid derivative of dihydrotestosterone with weak androgenic activity and a moderate anabolic effect . Available in tablets (Primobolan) and injectable (Primobolan Depot). Many athletes were compared for effectiveness and Masteron Primobolan.
Primobolan Depot – injectable form of the drug, which is an ester of methenolone enanthate. The injectable form has a duration of action (due to the gradual transition of the preparation of the muscles in the blood), approximately two weeks. For the duration of action of Primobolan Depot is similar to Testosterone enanthate. The main disadvantage of this form is painful injections. Less frequent injection acetate with short half-life of about two days.
Oral Primobolan – methenolone form of tablets (methenolone acetate), has a much smaller period (about 5 hours). Primobolan tablets have a higher price. A distinctive feature of the tablet form – no toxic effect on the liver, in contrast to most other forms of oral steroids.
Estimating overall methenolone two forms, most preferred the injectable form, due to the lower cost and more uniform intake of the active substance in blood. Moreover, some of the tablets Primobolan destroyed in the liver.
The steroid profile
Anabolic activity – 88% of the testosterone
Androgenic activity – 44% of testosterone
Aromatization (conversion to estrogen ) – No
Toxicity to the liver – Weak
A method of receiving – by mouth (tablets) and injection
The half-life – 5-20 hours in tablets; Days 4-7 injections
The anabolic effect of Primobolan is quite mild and comparable to Deca, so the drug is more commonly used during the drying cycle, where the main aim is not a set of muscle mass and its preservation. Methenolone has minimal rollback phenomenon, however, many athletes are dissatisfied with the results obtained after a cycle of Primobolan solo, if the goal was set of muscle mass.
Primobolan – side effects
Primobolan (both forms) can not be converted into estrogen, which is one of the main benefits of the drug. As a result, you can take Primobolan without the risk of gynecomastia and edema. Although gynecomastia may be indicated in some instructions.
Primobolan slightly reduces the level of own testosterone . Its overwhelming impact of weaker than testosterone and nandrolone. Studies suggest that Primobolan rate at a dose of 40 mg (oral) suppresses testosterone levels by an average of 50%. A significant reduction in endogenous testosterone production is only observed at long cycles with high doses of the drug . In these cases, the required rate during application of gonadotropin otherwise may develop testicular atrophy .
Methenolone is virtually raising bad cholesterol. The drug had no significant effect on blood pressure.
Due to low androgenic effect Primobolan practically does not cause baldness. Most often methenolone cause side effects such as: aggression, anxiety, insomnia, and the rise of liver enzymes in the event that used high doses.
Thus Primobolan can be considered one of the safest anabolic steroids available on the market at present.
Soft drug action requires a longer cycle (up to 8 weeks), however, with increasing duration Primobolan cycle, increases the risk of side effects.
Dosage Primobolan yelling – 50-100 mg per day. After 2-3 days after the deadline begins post-cycle therapy .
Dosage Primobolan Depot – 400 mg 1 time per week. 3 weeks after the last injection therapy begins aftertreatment.
Before starting the cycle you want to consult a doctor to rule out contraindications.
Combined cycles
Given the rather weak anabolic effect methenolone (its ability to increase weight slightly less than nandrolone), it is often combined with other drugs. Well Primobolan is combined with:
Nandrolone – for a set of muscle mass (one of the safest cycle , with good conservation of mass)
Do not include a combined rate of more than one drug. Use both steroid half-doses (recommended) – this will reduce the incidence of side effects of each drug and to increase the effectiveness of the cycle.
Turinabol (Oral) (chemical 4-hlorodegidrometiltestosteron.) – Anabolic steroid , which is similar in chemical structure and effects to methandrostenolone . The word “screaming” in the name means that the anabolic agent is administered orally (inside). Unlike methandrostenolone is Turinabol that contains an additional chlorine atom in the fourth carbon atom. The drug first developed by the German pharmaceutical company Jenapharm and patented in 1961.
Detection time – up to 250 days (long-lived metabolites are fat soluble)
History
To achieve success in the Olympic Games, since the 60s of the last century, Eastern Germany has developed a number of highly effective anabolic steroids, including drug oralturinabol. The developers describe it as a combined version of methandrostenolone and Oxandrolone with moderate anabolic effect (comparable to testosterone ) and low incidence of side effects. Creator is Albert Stachowiak.
Description
The preparation can be characterized as Methandrostenolone without effect of fluid retention in the body.
This delayed acting steroid. During the cycle Turinabol weight, power and performance relief progressing very slowly, but the results are better with the words of the athletes. Another distinguishing feature of the product – no estrogenic effects (because is not exposed to flavoring, by adding a chlorine atom in the molecule), ie side effects such as fluid accumulation, gynecomastia , etc. almost never occur. Although there are reviews, which reported on the development of gynecomastia, which is the development of the mechanism remains unclear. The most likely reason – the presence in the methyltestosterone , which is related to the synthesis features.
Also, it was determined that the concentration decreases SHBG, thus increasing the level of free testosterone in the blood. There is evidence that Turinabol reduces the risk of blood clots in blood vessels and heart.
Cycle
Test results at the end of the cycle, yelling Turinabol (in the last column shows the norm)
During the preparation of the Olympic Games in an optimal dose was chosen, which caused minimal adverse effektov- 20-40 mg per day, divided into three stages, but bodybuilders often neglect these figures, bringing the dose to 100-150 mg per day.
The preparation can be applied both in the recruitment of muscle mass, and drying. Turinabol cycle need not include anti-estrogens and gonadotropin (if not exceeds 6-8 weeks), but PKT carried blockers estrogen receptor ( tamoxifen ). Monokurs Turinabol is one of the easiest and safest in bodybuilding, so it is often recommended to beginners. For the first cycle is considered to be the optimal dose of 40 mg / day for 6 weeks. This allows you to get impressive results, both in terms of growth of quality muscle mass, as well as in the progress of speed-strength results.
For a set of muscle mass is the best combined cycle Turinabol (20 mg daily) + testosterone enanthate 250 mg per week (or + Sustanon). The average duration of 6 weeks. First enanthate is canceled, and a week later Turinabol.
Athletes who are not interested in a set of weights and seek to increase speed and endurance (boxers, wrestlers, runners, etc.) recommended a lower dose – 10-20 mg per day. However, it should be noted that in recent years oralturinabol become problematic in terms of anti-doping steroid, as recently discovered (2012), long-lived metabolites are determined in six – eight months. Great contribution to such an incredibly long period of detection made by the latest developments in the field of gas chromatography-mass spectrometry.
It should also be noted that on the black market found a lot of fakes (sometimes with another active principle), so that the results obtained do not always meet the expectations.
Side effects
Turinabol 17 is alkylated anabolic steroid, which enables oral administration, but creates a toxic effect on the liver, comparable to methandrostenolone. In general, side effects are rare and are most commonly associated with the excess of the cycle duration and high doses. This drug strongly inhibits the secretion of testosterone. Can erectile dysfunction after the cancellation, there have been cases of premature ejaculation.
Violations of the Liver: cholestatic jaundice, necrosis of hepatocytes with liver failure, liver cancer. From the biochemical parameters determined by increased levels of bilirubin, alkaline phosphatase and transaminases. Cholestatic jaundice may occur after 6 months or more (a toxic origin) and manifested stasis in the bile capillaries with hyperbilirubinemia and increased activity of alkaline phosphatase. When applying for several years may increase the frequency of liver cancer.
An official report of a carcinogenic effect was observed for 5 years of use Turinabol in relatively high doses.
Endocrine disorders: Turanabol less than other drugs in men can cause: inhibition of spermatogenesis and impotence (second decrease the secretion of gonadotropins and testosterone with testicular atrophy and oligospermia); prostatic hypertrophy (mainly in the elderly); epididymitis; priapism. The boys may experience precocious puberty, frequent erections, increase the risk of suspension.
Metabolic disorders : decreased glucose tolerance; increase the level of low-density lipoproteins (LDL); accelerated clearance of creatinine; elevated levels of creatine phosphokinase; swelling relatively rarely observed because of the low delay of sodium and water; delay potassium, calcium and phosphorus. Patients with prolonged bed rest can develop hypercalcemia .
Other : at puberty may prematurely closed epiphyseal bone areas with growth retardation.
In women, the drug can cause rare : decreased secretion of gonadotropins ; phenomena virilization (acne, hirsutism, deepening of voice, increase libido , menstrual disorders , hypertrophy of the clitoris, development of muscles). Pregnant women can develop virilization of the female fetus. The frequency of these side effects have Turanabol low.
If you decide to seriously take care of your body like Arnold or use bulking or cutting steroids, gain quality weight and become stronger in times when you present the M1T – great preparation for the extreme and incredibly high-quality growth of mass and strength! It contains in its composition two methylated prohormones: Methyl-1-testosterone, which work like a Swiss movement. Incredibly powerful product recommended for use only for experienced users! Let us consider in more detail the composition and then we will research Masteron.
Methyltestosterone (brand names Android, Androral, Metandren, Oraviron, Testred, Virilon), also known as 17α-methyltestosterone, is a 17α-alkylated anabolic steroid used to treat males with a testosterone deficiency.It bears close structural similarity to testosterone cypionate, but has a methyl group at C17 in order to increase oral bio availability. Due to aromatization to the metabolization-resistant estrogen 17α-methylestradiol, methyltestosterone has relatively high estrogenicity and hence side effects such as gynecomastia (read our Dbol review also)
Methyl-1-testosterone (M1T) – that anabolic was designed in the 50s of the twentieth century just like Boldenone Acetate. Past studies have shown time and again that M1T significantly improves the operation of any AAS, which is now available for sale just like Dianabol. That is why it is so widely popular among athletes. For the shortest possible time it helps to increase the meat several times to increase the power and performance to make your workouts are not just effective, but a truly brutal. Also it does not retain an amount of water as other pro-hormones, for example, Anapolon.
Methyltestosterone reporting component plays an important role in the rapid and effective muscle building without delay of excess fluid. Track performance with M1T will grow by leaps and bounds, and their continued existence can not be any doubts. Also, this prohormone is not as tough impact on the body’s system, like other hormonal agents. Furthermore, it is not converted to estrogenic compounds, and its safety is high (use Clomid or Tamoxifen).
One can find several offers of M1T for sale (Steroids for sale)
If you are prone to insane acts that subsequently lead to greater achievements, then definitely choose this product. You will not regret it, on the contrary, achieve incredible results, which will be pleasing to the eye for a long time.
M1T Dosage
M1T is intended only for experienced athletes, who is not the first year! Start your M1T Cycle with 1 capsule per day, for example in the morning after a meal. With good tolerability after a week of receiving increase to 2 capsules per day, such as morning and evening after meals. Traditional course of 4-8 weeks. Be sure to PCT and receive relaxing pills on the course.
Methyltestosterone significant side effects: head hair loss, severe acne, severe stress on the liver, severe weight gain (usually 90% of this water and fat). Prolonged ingestion increasingly there is a risk of gynecomastia. .
Another serious side effect is the strong effect on the psyche (depression, nervousness, mood swings, changes in libido, increased aggressiveness and violence). Medical methyltestosterone is displayed in injectable administration for the treatment of underactive gonads in men (hypogonadism), but the result of severe side effects no great medical significance from Anabolic Pharma.
Learn about most popular steroid that was ever invented
What does Anavar do when you take it after the workout is the main thing you should notice. the number of repetitions of any beginner should keep a relatively large number of repetitions. After starting to work for 6-12 repetitions with the first day, it is possible to engage with training on the second. The optimum number, in my opinion, equal to fifteen repetitions. Several reasons for this, and all of them are justified as long as your a little more experience. Firstly, a number of repetitions prepares budding connective tissue, ligaments and tendons in the future more than hard work. In addition, such a large number of repetitions will not allow a novice to work with weights that can hurt him. Even if a beginner’s enthusiasm gushes over the edge, as the protein from the blender.
Deca-Durabolin® is the Organon brand name for the injectable steroid nandrolone decanoate. This compound came around early in the wave of commercial steroid development, first being made available as a prescription medication in 1962. This steroid is an extremely long acting compound, with the decanoate ester said to provide this drug a slow release time of up to three or four weeks. While perhaps true in a technical sense, what we find with further investigation is that the release parameters after a single injection are such that a strong release of nandrolone is really only maintained for one to two weeks. This figure admittedly fails to take into account drug buildup that may occur after multiple injections, which may allow a longer duration of good effect to be seen. Figure 1 is provided to illustrate the release dynamics of a single 200mg injection. As you will see, by the end of the second week levels are already approaching baseline.
World Wide “Deca” is one of the most widely used anabolic steroids. Its popularity is due to the simple fact that it exhibits many very favorable properties. Structurally nandrolone is very similar to testosterone, although it lacks a carbon atom at the 19t” position (hence its other name 19-nortestosterone). The resulting structure is a steroid that exhibits much weaker androgenic properties than testosterone. Of primary interest is the fact that nandrolone will not break down to a more potent metabolite in androgen target tissuess’. You may remember this is a significant problem with testosterone. Although nandrolone does undergo reduction via the same (5-alpha reductase) enzyme that produces DHT from testosterone, the result in this case is dihydronandrolone. This metabolite is weaker than the parent nandroloness, and is far less likely to cause unwanted androgenic side effects. Strong occurrences of oily skin, acne, body/facial hair growth and hair loss occur very rarely. It is however possible for androgenic activity to become apparent with this as any steroid, but with nandrolone higher than normal doses are usually responsible.
Chemical Structure
Nandrolone is the base hormone, but it is better known under the trade name Deca Durabolin, which contains Nandrolone Decanoate. This popular preparation takes the nandrolone hormone and adds a decanoate ester chain. This ester chain is attached during the manufacturing process and it serves dual purposes. The main purpose is to make the hormone oil soluble, so it can be put in an amp or multi-dose vial. The second purpose of this ester chain is to slow-release the steroid by keeping deca from interacting with androgen receptors until the ester chain is cleaved off by enzymes in your body. Since nandrolone decanoate cannot attach to an androgen receptor until enzymes in your body have cleaved off the decanoate ester, it causes the steroid to slow-release into your system over many days. For medical use, the ester’s main function is to allow the hormone to be injected only once every 3 weeks. However, bodybuilders may inject deca durabolin weekly or as often as every three days.
What are the adviced Deca dosages ? How to use Deca better way?
By adding 400mg per week of nandrolone to a testosterone cycle or a dianabol cycle, you’ll be able to increase your overall steroid dosage, without increasing the side effects. For example, a bodybuilder taking 500mg Sustanon 250 per week, who felt he needed more power in his cycle, would find himself with more side-effects if he were to just take more of the same testosterone. Since testosterone aromatizes at an increasing rate at higher doses, there would be an exponential increase in the likeliness of gynecomastia and water retention if more testosterone was added weekly. When adding nandrolone decanoate to the same testosterone cycle, you are increasing the total amounts of steroids your body is receiving every week. However, you are not adding anymore viable substrate for undesired enzymatic reactions from aromatase and 5-reductase. In simple terms, you use more steroids without more side effects.
The dosage for men is around 400-600mgs per week but that varies depending on goals. I’ve seen guys use as little as 200mgs per week as a booster, and up to 1500mgs per week as a heavy bulker.
For women, we wouldn’t suggest using deca durabolin because of the side effects that are too variable from female to female.
Deca Durabolin Cycle
A Deca Durabolin cycle can be a very exciting cycle for most men. In most cases, a Deca Durabolin cycle will be during a period of growth and increasing muscle size is pretty exciting for most men. This is not the only time the steroid can be used; Deca Durabolin has a place in some cutting cycles and is commonly used by athletes who may not be bulking or cutting at all. However, the standard Deca Durabolin cycle will surround growth.
For many men, planning any steroid cycle can be very confusing, and it’s often complicated by misinformation that plagues the net and many local gyms. However, planning a Deca Durabolin cycle is actually one of the easiest cycles you’ll ever plan. With that in mind, we want to take a look at various plans and help you develop the right Deca Durabolin cycle for you. We will look at precise layouts, but it’s important to note these are merely guides and are by no means set in stone. The following Deca Durabolin cycles are simply presented in an effort to explain proper use, but total doses and stacking plans may need to be adjusted to meet individual needs.
*Bulking Deca Durabolin Cycle:
A bulking Deca Durabolin cycle will be the most common point of use for most men. With this plan, a simple stack of Deca Durabolin and testosterone can easily be all you need. The form of testosterone you choose is inconsequential; all that matters is your body is given adequate amounts of the testosterone hormone to meet its needs. However, higher testosterone doses are typically recommended during a growth phase. Large ester base testosterones will also be the easiest to use such as Testosterone Cypionate and Testosterone Enanthate. Some may also find additional steroids like Anadrol or Dianabol to be beneficial. In fact, the combination of Deca Durabolin and Dianabol along with some form of testosterone is one of the oldest and most popular steroid cycles of all time.
An important note – many inaccurately assume that other 19-nortestosterone (19-nor) steroids cannot be used with a Deca Durabolin cycle because they will compete for the same receptors. We’re not going to go into explaining receptor function but this idea is a myth. You do not have to use another 19-nor compound, most of you will not need one, but one can be used. It is also assumed that steroids like Equipoise cannot be used during a Deca Durabolin cycle for similar reasons; again, this is a myth. Deca Durabolin will stack well with most all anabolic steroids.
*Cutting Deca Durabolin Cycle:
A cutting Deca Durabolin cycle will normally not be built around this Nandrolone hormone, but rather it is a secondary addition. In the cutting phase, this steroid may be added to a total plan in order to promote muscle tissue preservation, but it is most commonly added for the therapeutic effects this steroid can provide. If a cutting Deca Durabolin cycle is implemented, especially if you’re a competitive bodybuilder, you will more than likely want to keep its use at the front end of the total plan and rely solely on hardening agents towards the end. This type of Deca Durabolin cycle cannot be recommended to new steroid users. This type of use will normally be extended beyond what a new steroid user will be comfortable with.
*Athletic Deca Durabolin Cycle:
Most any athlete can benefit from a Deca Durabolin cycle. In most cases, a low dose of Deca Durabolin will be used in conjunction with another steroid that promotes strength to a higher degree along with a very low dose of testosterone. It’s not uncommon for many athletes to rely on testosterone gel but low dose injections will prove to be best.
*Sample Deca Durabolin Cycle:
Below we have provided a sample Deca Durabolin cycle for all points of use. We have provided two for off-season use, one is moderate and the other far more advanced. We have also included one Deca Durabolin cycle for cutting, and while it’s not the only possible plan it will not be a plan suited for most new steroid users. Then we’re left with athletic enhancement, and this Deca Durabolin cycle while highly effective comes with a warning. If you are a tested athlete this is not a plan you’ll want to follow.
On the black market Deca remains one of the most popular anabolics in circulation. Currently 200mg/ml preparations from Mexico are dominating the marketplace, and due to their high availability and lower cost are minimizing the appearance of lower dosed compounds. For example, in addition to Norandren 200 Brovel also makes Norandren 50 (a 50 mg/ml version of this steroid), but it is almost unseen right now. I should point out that their 50m1 vial of Norandren 200 is also the largest container of nandrolone to be found in such strength, and represents one of the best values anywhere for this steroid. We can see why it is much more desired right now. Also common are Nandrolona 200 from Tornel and Decanandrolen from Denkall, both in 1 Oml vials. In an effort to provide more innovative, conspicuous and cost-effective products, the Mexican firm Ttokkyo has recently topped its competitors and released Nandrolona 300. This is a 300mg/ml preparation of nandrolone decanoate, which is by far the highest dose of this compound ever to be produced commercially. To spite the defiant opinions of many, indeed this is a legitimate product. I have not experimented with the solubility of nandrolone decanoate myself, but do know that this particular ester is highly fat-soluble. Reaching 300mg in a milliliter of oil does not seem like an unreasonable or impossible task, and I would guess requires at best some minor tweaking of alcohol levels (perhaps none at all).
Not a rapid mass builder, instead Equipoise® will be looked at to provide a slow but steady gain of strength and quality muscle mass. The most positive effects of this drug are seen when it is used for longer cycles, usually lasting more than 8-10 weeks in duration. The muscle gained should not be the smooth bulk seen with androgens, but very defined and solid. Since water bloat is not contributing greatly to the diameter of the muscle, much of the size gained on a cycle of Equipoise® can be retained after the drug has been discontinued. It is interesting to note that structurally Equipoise® and the classic bulking drug Dianabol are almost identical. In the case of Equipoise® the compound uses a l7beta ester (undecylenate), while Dianabol is 17 alpha alkylated. Aside from this the molecules are the same. Of course they act quite differently in the body, which goes to show the 17-methylation effects more than just the oral efficacy of a steroid.
As discussed earlier, Equipoise® is a very versatile compound. We can create a number of drug combinations with it depending on the desired result. For mass, one may want to stack it with Anadrol 50®(oxymetholone) or an injectable testosterone such as Sustanon 250. The result should be an incredible gain of muscle size and strength, without the same intensity of side effects if using the androgen (at a higher dose) alone. During a cutting phase, muscle hardness and density can be greatly improved when combining Equipoise® with a non-aromatizable steroid such as trenbolone acetate, Proviron® (mesterolone; 1-methyl DHT), Halotestin® (fluoxymesterone), or Winstrol® (stanozolol). For some however, even the low buildup of estrogen associated with this compound is enough to relegate its use to bulking cycles only.
Presently, for the most part there is little specific reason to use Equipoise in an anabolic steroid cycle. There is nothing that it does anabolically that Masteron, Primobolan, Deca, or trenbolone will not do. In terms of side effects, likewise it has no advantage over Masteron or Primobolan, unless one desires the occasional side effect of increased appetite, or the side effect of its moderate conversion to estrogen. This can be useful if no other aromatizing steroid is being used.
Effectiveness of Equipoise
This is not intended to disparage the compound: it certainly can be put to good use in a steroid cycle. Its potency (effect per milligram) is comparable to most other injectable steroids, though less than that of trenbolone, and so for example addition of 400 mg/week is a substantial boost to most cycles. Alternately, if substituting boldenone for another injectable this can be done on a milligram-for-milligram basis.
Equipoise® is not an ideal steroid for the drug tested athlete however. This drug has the tendency to produce detectable metabolites in the urine months after use, a worry most commonly associated with Deca-Durabolin®. This is of course due to the high oil solubility of long chain esterified injectable steroids, a property which enables the drug to remain deposited in fatty tissues for extended periods of time. While this will reliably slow the release of steroid into the blood stream, it also allows small residual amounts to remain present in the body far after the initial injection. The release of stubborn stores of hormone would no doubt also be enhanced around contest time, a period when the athlete drastically attempts to mobilize unwanted body fat. If enough were used in the off-season, the athlete may actually fail a drug screen for boldenone although many months may have past since the drug was last injected.
How Equipoise should be used
As an undecylenate ester, boldenone needs only be injected every week (staying active well over 4 weeks), but because the preparations come in 25 mg/ml, users most often opt for 25-50 mg every day to every other day. A use of 300-400 mg per week seems to be the normal recommendation. Its not hepatoxic to any serious degree and can therefore be used for longer cycles. The appearance of underground forms of boldenone in higher concentrations (200 mg/ml) has made it easier to inject only once a week, which is to be preffered over the multiple dosings because it has a more even release and the cumulative effect shows much sooner. Speaking of cumulative effect, the best results with boldenone are seen when a user front-loads. Usually that means he will use a high doses of 600-800 mg/week for 2 weeks and then lower that dose to the normal 300-400 mg/week for the remaining 8-10 weeks.
Chemically, boldenone undecylenate is almost identical to methandrostenolone (dianabol). There is only one structural difference between these two anabolic agents. Dbol is an oral steroid with a c17 alpha alkylated group (c17aa) added in order to survive the first liver pass. On the other hand, equipoise is not an oral steroid, and it therefore doesn’t need the c17aa group in its structure. What it does have, is the undecylenate ester, which provides a slow release rate into the system after being injected.
For some reason equipoise seems to be a very underrated steroid. One can agree that it doesn’t give extreme mass gains, nor is it fast. However, many tend to forget that apart from anabolic effects, its main property is mass preservation. Therefore, since it will help preserve a lot of lean mass gains, EQ can be a very useful stacking steroid both for cutting, and bulking anabolic androgenic steroids (AAS).
Besides, its side effects are very mild. The weak side effects and slow mass gains require long cycles in order to appreciate noticeable results. Even if these will not be clearly visible right away, one can be sure that strength and endurance will be considerably enhanced.
Due to its outstanding nitrogen retention ability equipoise helps to have some very hard and well defined muscles, and will perfectly fit in a stack with Trenbolone or Winstrol.
Tamoxifen Citrate is a Selective Estrogen Receptor Modulator (SERM) that was created in 1961 by ICI now known as AstraZenaca. There are numerous brands including generic forms of Tamoxifen Citrate on the market, but Nolvadex is the most well known. Often referred to as an anti-estrogen, Tamoxifen Citrate is actually both an antagonist and agonist. This means it will act as an anti-estrogen in certain areas of the body while acting as an estrogen in other areas.
Tamoxifen Citrate (often sold as Nolvadex) has been used medically for decades and has been highly successful in breast cancer treatment, specifically hormone-responsive breast cancer. It is also a medication that is used by many anabolic steroid users, but it is not a steroid. This is a drug steroid users will sometimes use during steroid use to help with estrogenic related side effects brought on by specific steroids. However, it is most commonly used during Post Cycle Therapy (PCT). PCT is the 3-6 week period following steroid use that is implemented in order to help with natural testosterone production that is suppressed during anabolic steroid use.
A concern about anabolic steroid use is the resulting suppression of natural testosterone production. During an anabolic steroid cycle itself, this suppression is unavoidable and isn’t necessarily a problem. However, extended post-cycle suppression results in loss of gains and can result in adverse side effects such as depression and loss of libido. In contrast, where recovery of natural testosterone production is rapid, adverse effects on mood or libido can be reduced or eliminated, and retention of gains can be excellent. Post-cycle therapy (PCT) with Nolvadex was introduced specifically to enable faster recovery.
To understand how Nolvadex can speed recovery, it’s important to understand how inhibition occurs, and how it may be reversed by a selective estrogen receptor modulator (SERM) such as Nolvadex.
Testosterone production is regulated in a chain process. The testes produce testosterone according to the amount of LH the pituitary produces. The pituitary produces LH according to the amount of LHRH the hypothalamus produces, as well as other factors. And the hypothalamus produces LHRH according to the current amount of estrogen and androgen in the blood, as well as other factors.
Off-cycle, estradiol will typically be the most important estrogen in this process and testosterone the most important androgen, but in an anabolic steroid cycle, the androgen could be any anabolic steroid.
For the moment, we’re going to assume that in an individual testosterone and estradiol are in a fixed ratio to each other. This usually is approximately true, because estradiol is produced from testosterone. When we look at things this way, then we’ll take it that when testosterone rises or falls, estradiol will rise or fall as well.
In the normal condition – while not using anabolic steroids and being in good health – this process results in a balance where testosterone and estradiol remain in the normal range. If briefly they were to go relatively high for the individual, LHRH and LH production would decrease, reducing testosterone production and normalizing the levels.
When looking for a stronger antiestrogenic effect, Proviron® can make a good adjunct to Nolvadex®. Although this compound is technically an androgen, it may have a pronounced effect on the production of estrogen in the body. Its mode of action is therefore very different than that of Nolvadex®. While Nolvadex® only blocks the binding ability of free-floating estrogen, Proviron® can minimize the creation of it. With each drug attacking estrogen via a different mechanism, we have a very synergistic combination. A daily intake of 20-30mg Nolvadex® and 25-50mg Proviron® can be extremely effective when dealing with a strong estrogenic cycle. Women often avoid adding Proviron® to Nolvadex® treatment (thought often it is still used to enhance fat loss), for fear of developing virilization symptoms (Proviron® is an oral DHT). Virilizing effects can occur very quickly once there has been a dramatic rise in the activity of androgens (intensified by a decrease in estrogen activity), so at a minimum women should be careful with such a combination.
Of great interest also is that Nolvadex is an estrogen agonist in the liver, capable of activating the estrogen receptor and mimicking the actions of this sex hormone in this region of the body. As such it can have a markedly positive impact on HDL (good) cholesterol valuesas, as does estrogen. Many similarly use this drug to counter some of the negative consequences of steroid use in regards to cholesterol values and cardiac risk, as steroids often suppress HDL and raise LDL levels considerably. in some instances I have heard an athlete being able to maintain a very favorable HDULDL cholesterol ratio, to spite the use of a moderate dosage (400mg weekly) of an injectable like testosterone or nandrolone. It would probably be foolish to think however that Nolvadex® would be a sufficient remedy with the heavy use of c-l7alpha alkylated orals or extremely high dosed cycles in general.
It has been reported by many however that Nolvadex® seems to slightly reduce to gains made during a steroid cycle. It appears that many androgenic/anabolic steroids will exhibit their most powerful anabolic effect when accompanied by a sufficient level of estrogen (See: Estrogen Aromatization). This may be one reason why gains made with a strong androgen like testosterone are usually much more pronounced than when using an anabolic that aromatizes to a lower degree. It therefore seems like good advice to be aware of how much Nolvadex® is actually needed before committing to it during a cycle. Many people in fact find it unnecessary, even when utilizing problematic compounds such as testosterone or Dianabol. Others however find they are troubled by water retention and gynecomastia, even with milder anabolics like Deca-Durabolin® and Equipoise. The estrogenic response to steroid use is very individual, and may be influenced by factors such as age and body fat percentage (adipose tissue is a primary site of aromatization).
While the use of tamoxifen citrate may be beneficial in the blocking on estrogenic effects, a stronger option may be needed, and for this we would look to opt for an anti-aromatase. Whilst an oestrogen agonist/antagonist such as tamoxifen citrate only blocks oestrogens effects, an anti-aromatase will work by slowing or halting the production of oestrogen in the first place. This may be of a more beneficial option for those using heavier cycles, or those prone to related side effects, as this methods is a lot more effective. The combination of both type of drugs may be fruitful by ceasing estrogenic effects via both mechanisms.
Somatropin is a type of synthetic human growth hormone, also known as HGH, that is used for a variety of medical applications. HGH is produced naturally in the body through the pituitary glands and can also be extracted and administered as a supplement. Somatropin is often used to treat patients with growth hormone deficiencies and is sometimes employed by body builders to increase muscle mass, although there are legal ramifications for taking somatropin without a prescription.
Effects of Somatropin
The pituitary gland’s secretion of somatotropin supports bodily growth and development throughout childhood and adolescence, so the most common reason for prescribing somatropin is to treat children and teens with HGH deficiency or specific medical conditions. FDA-approved pediatric uses of somatropin include idiopathic growth hormone deficiency, Noonan syndrome, Turner syndrome, Prader-Willi syndrome, chronic renal insufficiency, short stature homeobox-containing gene (SHOX) deficiency, and idiopathic short stature.
Although HGH levels naturally decline with age, somatotropin continues to play a role throughout adulthood—helping to regulate metabolism and protein synthesis and promoting organ, tissue and bone health. Somatropin may be legally prescribed to adults who have severe HGH deficiency, which normally occurs due to a pituitary adenoma (tumor) or adenoma-related surgery or radiation treatments. It is also sometimes prescribed to prevent or minimize wasting in AIDS patients.
Somatropin injections can improve bone density, muscle mass and exercise capacity in adults with HGH deficiency, and they can produce similar outcomes in healthy adults. As a result, some bodybuilders and athletes take somatropin to enhance their athletic performance and physique. However, it should be noted that somatropin cannot legally be prescribed for such purposes. Furthermore, the World Anti-Doping Agency (WADA), International Olympic Committee and numerous sports organizations have banned the use of HGH injections among athletes.
Given the potential repercussions associated with illegal somatropin injections, many bodybuilders, athletes and aging adults have starting taking natural HGH supplements to help the body increase its own somatotropin production. Proponents of somatotropin-boosting supplements report that these natural HGH releasers have helped them develop lean muscle, improve their strength and endurance, and recover from intense workouts and injuries more quickly. They also credit HGH supplements with enhancing their body composition and slowing the visible signs of aging.
The effects of Somatropin cover a wide range of areas and can lead to dramatic improvements all over the human body. This is a compound that’s most commonly used to treat pituitary dwarfism or GH deficiency in adults in medical settings, which can occur for numerous reasons. It is also used in HIV and AIDS treatment, burn victims, short bowel syndrome and Prader-Willi syndrome. However, in recent years the most common reason for use (medically) has become anti-aging. Anti-aging use is common worldwide but far more common outside the U.S. The drug is very expensive (heavily in the U.S.) and laws still make anti-aging practices somewhat difficult in the U.S.
For the athlete, Somatropin is a highly beneficial compound although not commonly one that’s used alone. When used alone the primary benefit is anti-aging and most athletes are looking for a lot more. This is an anabolic hormone, but not well known for promoting significant growth. However, when combined with anabolic steroids the results can be incredible. Somatropin and anabolic steroids appear to work very well with one another. You can take a steroid alone and then take it with Somatropin in the same dose and the cycle that included Somatropin will always yield superior results.
One of the best traits of Somatropin for the athlete is in its ability to promote recovery. Recovery is when progress is made and without it no progress is made. The more we can improve on the recovery process the greater our progress can be. This can make use alone and without other hormones very valuable, but there are things that must be understood. It takes months and months for these types of benefits to become truly beneficial. You can’t take Somatropin for a few weeks and expect to hold a benefit. And if recovery is the only benefit you’re after (truly valuable) because it’s not as “visual” as mass and strength some become frustrated too quickly.
Minor Side Effects
Somatropin may interact with other medication, so it is important to disclose this information to your doctor to reduce the risk of serious side effects. It is uncommon to encounter serious side effects when all other medications and medical problems are taken into consideration and if somatropin is taken as prescribed. However, there are some common minor side effects, which include headaches, joint pain including stiffness or swelling, nausea or stomach pains and minor rashes at the injection site.
You can buy Somatropin online with relative ease, but there are many issues of concern. As discussed this isn’t a cheap product and counterfeits and low grade products run rampant. If you live in the U.S. and buy Somatropin online, understand you are breaking the law as this is a prescription only medication. Laws may vary from one country to the next making understanding the law in your country imperative.
The protein synthesis and nitrogen retention are considerably increased with the help of the anabolic moderate androgenic called Stanozolol. You will not experience any water retention, gyno, or female pattern fat deposits since this medication does not aromatize to estrogen. In order to obtain the best results, it is important to consume a diet rich in protein of 1.5-2-g of protein per lb of bodyweight. Apart from the fact that you will see rapid results, the high quality lean muscle mass will last for a long period of time after you interrupt the usage.
Since this drug provides continuously harder appearance, numerous bodybuilders used Winstrol as a pre-contest drug. Really impressive results can be obtained by combining 50-100mg every 1-2 days with 76mg of parabola every 2-3 days. For water retention and aromatization control, it is also important to add masteron, equipoise, or testosterone propionate/testosterone suspension in this combination. The use of winstrol depot was also reported by women. No virilization effects were declared by those that consumed 25mg 2-3 times weekly.
Other
In female patients the use of anabolic steroids has resulted in virilization including deepening voice, hirsutism, acne, clitomegaly (not reversible), and menstrual abnormalities. Discontinuation of stanozolol at signs of mild virilization may prevent irreversible virilization.
Stacking and Use:
Winstrol is best used at a rate of 50 mg a day. When in an injection that amounts to a single injection every day around the same time. In orals, that’ll be at least 5 tabs of a legit product.
In a mass stack Winny makes a good match for Deca and Nilevar. Whether or not its anti-progestagenic effects are for real or not, lets just say it can’t hurt. In any stack with Deca the use of 25-50 mg a day for the first 6-8 weeks of the stack can kickstart it and add some strength. With Nilevar there is a practical objection because it is also 17-alpha alkylated and more toxic than Winny, so your stack would be limited to 6 weeks, which is not overly productive.
Shape your body fast with Stanozolol Injection. This anabolic steroid is from Genesis manufacture. Buy Stanozolol quickly to your home. Order with our steroid shop online.
Buy the best quality Winstrol on market. This cutting steroid from manufacture of Genesis is called Stanozolol Injection. You will get lean and hard muscle with this anabolic steroid. This anabolics is mostly used by athletes, sprinters etc. You will feel muscle endurance and consistency.
Liver Tumors and Liver Cancer
Using anabolic steroids such as Winstrol may lead to serious side effects on the liver, including liver tumors and the development of liver cancer. This is considered to be a rare but extremely serious side effect of Winstrol injections, and liver tumors and liver cancer are more likely to occur in long-term, high-dosage treatments.
Injectable trenbolone acetate was first released for use in the cattle industry in the 1980’s under the name Finajet. At the time, it contained the short acting acetate ester. This Trenbolone preparation was used to beef up cattle right before slaughter.
Trenbolone Hexahydrobenzylcarbonate is also known as Trenbolone Cyclohexylmethylcarbonate, these are two names for the exact same ester chain. This was the very first incarnation of Trenbolone ever made for human use by a pharmaceutical brand (Negma out of France). The manufacturer discontinued the product in 1997 and no other forms of human grade trenbolone have been available since then. All of the Trenbolone on the black market today is either veterinarian grade or made in underground laboratories.
In the late 1990’s when Parabolan was discontinued, the only, and last, human grade trenbolone product disappeared, so bodybuilders started extracting the trenbolone acetate hormone from cattle pellets sold under the brand Finaplix H. The pellets were not meant for human use, but rather as cattle implants to be punched behind the animal’s ear with a pellet gun. Creative bodybuilders used solvents and filters to extract the hormone from the pellets into a vial with injectable oil.
What tren can do FOR you
Trenbolone is highly androgenic, up to five times more potent than testosterone, as far as muscle building is concerned. Unlike testosterone-enanthate, however, tren maintains highly androgenic characteristics, because it doesn’t aromatize, so it won’t convert to estrogen. (It does, nonetheless, behave like a progestin, so gynecomastia can still be a side effect, in the absence of appropriate countermeasures.)
It is extremely anabolic, allowing for larger and greater numbers of muscle fibers to be created, while minimizing water retention. For bodybuilders seeking the ripped look that turns judges’ heads, this alone may be sufficient reason to consider trenbolone. The accelerated bulking process this steroid provides is one bonus, with almost no water retention being another.
Because of tren’s ability to bond to the glucocorticoid receptor, it is widely used for rapid fat-burn and muscle mass build-up, and it’s often combined with other compounds to achieve specific results and to mitigate side-effects. Many bodybuilders that have utilized a wide array of anabolic steroids consider tren to deliver the best results, even though it may carry harsh side effects.
Bulking vs. Cutting
Trenbolone Acetate has a place in both bulking and cutting cycles. Not only does it put the body in a prime anabolic state for muscle growth, but it also inhibits glucocorticoid hormones, which are responsible for creating fat deposits in the arms, thighs, and abdominal areas. In a bulking cycle, Tren primes the body by putting it in an anabolic state. While cutting, Tren helps you hold on to gains as you cut calories and increase the intensity of your workouts. It is all about your diet and exercise plan, as well as your dose.
Sustanon 250 is a popular testosterone blend (mixture) and is without question the most popular and well known blend ever made. Manufactured by Organon, the idea behind Sustanon 250 was to provide the best of small (short) and large (long) ester testosterones in a single compound. This would allow the individual to maintain stable blood levels of the testosterone hormone with an infrequent injection schedule while simultaneously receiving fast acting benefits.
The limited injection frequency makes Sustanon 250 a perfect compound for the treatment of low testosterone. It allows the individual to maintain stable levels without the need for constantly pinning themselves with a needle, but this is truly the only advantage of this testosterone. Sustanon 250 will not provide any advantage over a single ester testosterone compound to a performance athlete. In a performance capacity we will find the individual will still be required to inject the hormone frequently if he is to maintain not only stable blood levels but peaked blood levels. Many often inaccurately assume Sustanon 250 is superior over single ester testosterone forms due to the fact that it carries four distinct testosterones in a single injection. As for the basic functioning traits of testosterone, they will be the same with Sustanon 250 as they are with all testosterone forms. They will be no more or less powerful or effective.
Sustanon 250 contains, per mL, short-acting testosterone propionate, 60 mg of testosterone phenylpropionate, 60 mg of testosterone isocaproate, and 100 mg of testosterone decanoate. The first, testosterone propionate, is short-acting and gives Sustanon a quick onset of action in a steroid cycle. The other esters are medium to long-acting. Sustanon is almost identical as Omnadren. But in Sustanon is extra testosterone isocaproate and testosterone decanoate. Sustanon is produced in Egypt, the Netherlands, Turkey, Pakistan.
Sustanon has been working since the first day due to testosterone propionate and phenylpropionate. As a final act ceases ester decanaote around third to fourth week after administration.
Sustanon is among middle androgens cause acne, increased aggression and sexual desire. After completion of bark Sustanon is a need to take HCG, Clomid. Dale Sustanon causes water retention in the body.
DOSAGE
Beginners use a dose of 400 mg per week, which is the standard testosterone injection once a week. This dose should produce dramatic increases in strength and muscle mass. Intermediate users will generally make much progress at doses of 400-8000 mg per week. Advanced users will make great progress at the same dosage as intermediate users, and rarely need to rise above this amount. In any case, advanced users tend to use T-400 ranging from 400 to 1200 mg per week. Detection time of T-400 in urine is 4-6 months.
250mg per Week
At a usage level of 250 mg/week, Sustanon provides basically only a high level of testosterone replacement therapy. Individuals with low testosterone may see a marked improvement, but many with mid-normal or high natural testosterone will see little added effect at this dosage level. Yet, Sustanon is suppressive of the hypothalamus and pituitary at this dosage and will largely shut down natural testosterone production while being used. So, this dosage has relatively little of the benefits of most steroid cycles, but shares the adverse side effect of suppressed testosterone production.
Buy Sustanon 250 Online
If you want to make a purchase, the easiest and most affordable way is to buy Sustanon 250 online. There are seemingly innumerable large internet suppliers, and almost all of them carry Sustanon 250. If they do not carry the Organon label, most will at least have another form. This is also a very common anabolic steroid among gym suppliers, but if you buy Sustanon 250 online you’ll find it to be less expensive. However, it will still cost more than most testosterone compounds.
You can easily buy Sustanon 250 online, but it comes with a few warnings. There’s always the risk of being scammed. You run the risk of sending your money and receiving no product in return. However, there are plenty of good suppliers if you take the time to hunt them down. Another risk is a low dosed or contaminated product. Again, this makes researching your supplier imperative. Then we’re left with the biggest risk of all, and it revolves around legality. In the United States anabolic androgenic steroids are classified as Schedule III controlled substance. In order to legally purchase and possess an anabolic steroid in the U.S. you must have a prescription. The prescription must also be based on medical need that is considered an approved medical need by the U.S. government. As Sustanon 250 carries no U.S. FDA approval it will be impossible to buy this steroid legally in the United States. You will find similar laws in other countries, however, rarely as strict as the U.S. You will also find numerous countries around the world that are far more lenient. Despite a much more relaxed atmosphere in many parts of the world, an online purchase is generally illegal in most countries.
Due to the strict steroid laws of the U.S. and other parts of the world, if you are looking for high quality anabolics you are encouraged to visit the sponsors here at Steroid.com. We provide you with quality anabolic products that are not only safe but 100% legal. You will not be at risk of being scammed or at risk for any legal punishment.
Testosterone is the primary male sex hormone. It is the responsible for producing mainly male-specific sexual traits. When synthesized, it is usually attached to an ester to delay its release into the body. Testosterone Propionate is the shortest commonly ester attached to the Testosterone hormone. This means it takes your body the least amount of time to rid itself of the ester and release the parent hormone into the body. Due to its short active life, testosterone propionate typically needs to be injected every other day at a minimum. Anecdotally, testosterone propionate causes the least side effects and the least bloating; these side effects usually subside very quickly when use is ceased.
Testosterone is an antagonist of female sex hormone – estrogen, has an antitumor effect in breast tumors in women. It has anabolic effects, resulting in a stimulation of protein synthesis, decreasing fat deposition, keeping necessary things for the synthesis of protein, potassium, phosphorus, sulfur, enhancing fixation of calcium in the bones and increasing muscle mass. With sufficient protein diet it stimulates the production of erythropoietin.
Effects
Testosterone propionate has a specific androgenic effect: it stimulates the development and function of the external genitalia, prostate, seminal vesicles, and the secondary sexual characteristics in men (voice, hair). It participates in the formation of the body constitution and sexual behavior in men, stimulates the libido and potency, and stimulates spermatogenesis. It reduces the production of luteotrophic and follicle-stimulating hormone.
Before using testosterone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as sesame oil), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: cancer (such as breast cancer in men, prostate cancer), blood clots (such as in the leg, lungs), heart disease (such as heart failure, chest pain, heart attack), stroke, liver problems, kidney problems, high cholesterol, high blood pressure, enlarged prostate, sleep apnea, diabetes.
If you have diabetes, this product may decrease your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor right away if you have symptoms of low blood sugar, such as increased hunger, dizziness, or unusual sweating. Your anti-diabetic medication or diet may need to be adjusted.
This drug may affect your cholesterol and may increase your risk of heart or blood vessel problems (coronary artery disease). Your doctor will monitor your cholesterol level closely.
Tell your doctor if you become bed-ridden (unable to walk) for a prolonged time while using this medication. Your doctor may monitor your blood calcium level to prevent problems.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Caution is advised when using this drug in children because bone growth may be affected, causing shorter adult height. Your child’s doctor will monitor growth and bone development during treatment.
Older adults may be more sensitive to the side effects of this drug, especially prostate/liver problems, swelling of arms/legs.
This medication must not be used during pregnancy. It may harm an unborn baby. Discuss the use of reliable forms of birth control (such as condoms, birth control pills) with your doctor. If you become pregnant or think you may be pregnant, tell your doctor right away.
It is unknown if this drug passes into breast milk. It may affect milk production and it may harm a nursing infant. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.
Underground labs and their brand names
There are countless of underground producers of Testosterone Propionate. Some are proper labs who follow good manufacturing practices and have adequate equipment operated by knowledgable staff. Majority however are just “bathtub pharmacies” created in someone’s back room. They order raw materials from Asia, mix it together and repackage into vials – the end user can only hope it was done in sterile environment.
There are too many underground brands to list and new one are created more or less daily. Some of the names are:
TestP 100 by Big D Pharma, Prop 100 by Centrino Labs, Testosterone Phenyprop by Hulk Labs, Propionate by ARL, GP Test Prop 100 by Geneza, Testoprogen by United Hardcore Pharmaceuticals, Testodex Propionate 100 by Sciroxx, Viro-Prop by ROHM, Propionate 200 by Max Pro, Testabol Propionate by British Dragon EU, Testpronate 100 by Pro-chem, Lixus Prop by Lixus Labs, TestoRapid by Alpha Pharma, Testaplex P 100 by Axio, Propionat 100 by Dragon Pharma, Test P 100 by Optimal Labs, Veyron Pharma TP 1.0 by Veyron Pharma, Testos-P 100 by Pharmacom Labs, Testolic by Body Research, Propiobolic by Asia Pharma, Testabol Propionate by British Dragon, TestoPro 200 by Casablanca, TP 100 by P.E.A., Propitrex by Concentrex, Propionate 1000 by Muscle Pharma, Propioplex by Sarcoplex, Test-Prop 100by UniGen, and at least a hundred more.
Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted from the testes of males. In females, it is produced in the ovaries, adrenal glands and by conversion of adrostenedione in the periphery. It is the principal male sex hormone and an anabolic steroid. In both males and females, it plays key roles in health and well-being. Examples include enhanced libido, energy, immune function, and protection against osteoporosis. On average, the adult male body produces about twenty times the amount of testosterone than an adult female’s body does. In the body, this ester form of testosterone is hydrolyzed rapidly and become actively available as testosterone. Testosterone Propionate is a short acting oil-based injectable formulation of testosterone. Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels. In addition, this agent promotes the maintenance of male sex characteristics and is indicated for testosterone replacement in hypogonadal males. (NCI04)
Background
Testosterone was the first anabolic steroid developed, in the 1930’s. It has been used as the most potent mass builder for decades. Brand names of testosterone propionate include “Testovis” and “Virormone.”
Testosterone undecanoate or testosterone undecylate androgel is an ester of testosterone. This hormone is used in androgen replacement therapy primarily for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive. It is sold and distributed under the brand names Aveed, Andriol, Undestor, Nebido, Pantestone, Restandol, Cernos Depot, Nebido-R and Reandron 1000.
Andriol (testosterone undecanoate) is an orally-active version of the anabolic steroid testosterone developed by Organon. This version of testosterone is based in oil and is sealed in a capsule to be taken orally. According to the manufacturer, this method bypasses the liver and enters the body as a fat through the lymphatic system.
In theory this seems quite interesting, however, athletes find Organon’s claims about Andriol don’t hold up well. In doses of less than 240mg per day effects are generally non-existent. With higher doses, effects are small at best. This leads one to think most of the steroid is not making it to circulation.
Generally, steroid users experienced with any strong anabolics will be disappointed with Andriol’s results. Combined with other anabolics androgel it may lend some effectiveness but should be questioned.
Unlike other oral steroids, Andriol does not go through the liver, instead it goes through the lymphatic system. This allows the steroid to avoid being destructed by the liver, and enter the blood stream, intact. Interestingly, this would set it apart from the other oral steroids which are 17-aa or methylated.
General profile information:
If you have any questions about testosterone undecanoate, please talk with your doctor, pharmacist, or other health care provider. Testosterone undecanoate is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take testosterone undecanoate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about testosterone undecanoate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to testosterone undecanoate androgel. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using testosterone undecanoate.
Product Description
What it looks like Andriol Testocaps packs are available in 3, 6# or 12 sachets, each containing a blister pack with 10 capsules. Andriol Testocaps capsules are soft oval, glossy, transparent orange coloured capsules with DV3 ORG printed in white. They contain a yellow oil. # commercially available pack. Ingredients Each Andriol Testocap capsule consists of 40 mg of testosterone undecanoate androgel (equivalent to 25.3 mg testosterone) in castor oil and propylene glycol monolaurate. The capsule shells contain the following inactive ingredients: gelatin, glycerol, medium chain triglycerides, lecithin, sunset yellow FCF CI15985 and printed with Opacode WB monogramming ink (ARTG proprietary ingredient 3883). If you have any further questions or require the full prescribing information for this medicine, please consult your doctor or pharmacist. Supplier Andriol Testocaps is supplied: In Australia by: Merck Sharp & Dohme (Australia) Pty Limited Level 1 Building A, 26 Talavera Road, Macquarie Park, NSW 2113 Australia In New Zealand by: Merck Sharp & Dohme (New Zealand) Ltd PO Box 99 851 Newmarket Auckland 1149 New Zealand Australian Registration Number: AUST R 92904 This leaflet was prepared in October 2015.
Side Effects
Nausea, vomiting, headache, skin color changes, increased/decreased sexual interest, oily skin, hair loss, and acne may occur. Pain or redness at the injection site may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects when it is used at normal doses.
Tell your doctor right away if you have any serious side effects, including: breast swelling/tenderness, mental/mood changes (such as depression, agitation, hostility), unusual snoring or difficulty breathing during sleep, swelling hands/ankles/feet, symptoms of liver problems (such as loss of appetite, persistent nausea/vomiting, severe stomach/abdominal pain, yellowing eyes/skin, dark urine), trouble urinating, too frequent/prolonged erections, fast/irregular heartbeat.
Get medical help right away if you have any very serious side effects, including: shortness of breath/rapid breathing, chest/jaw/left arm pain, unusual sweating, confusion, sudden dizziness/fainting, pain/swelling/warmth in the groin/calf, sudden/severe headaches, trouble speaking, weakness on one side of the body, sudden vision changes.
Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, get medical help right away, or permanent problems could occur.
This medication can decrease sperm production, an effect that may lower male fertility. Consult your doctor for more details.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Andriol effects
Testosterone androgel is the male hormone responsible for gaining muscle, losing fat, gaining strength and other man-like features. Bodybuilders will utilize hormones such as testosterone as performance enhancing drugs during cycles. Usually, pure testosterone can serve as a safe and low side effect way to get a test base during a cycle.
Although it is considered a weak steroid, andriol will still have positive effects on recovery, workouts, and libido when used at higher dosages. Bodybuilders who do not want to inject, or use topicals due to allergies or convenience, can use oral andriol instead without fear of damaging their livers.
It is not recommended you run andriol alone, as it is too weak to see results. If you don’t stack it, you’ll see results comparable to using proviron alone.
Before you use Andriol Testocaps
Do not use Andriol Testocaps if you
have or have had a tumour of your prostate or breast, or are suspected to have one of these tumours.
you have or have had severe kidney disease
you are allergic to testosterone undecanoate or any of the ingredients listed under Product Description, at the end of this leaflet.
Do not use Andriol Testocaps if the packaging is torn or shows signs of tampering.
Before you start to take it
Andriol Testocaps may not be suitable for you if you suffer from certain medical conditions. Tell your doctor or pharmacist before you start using this medicine if you ever had, still have, or are suspected to have (particularly if you are elderly): heart disease, high blood pressure or blood vessel problems Diabetes mellitus, Kidney disease Kidney or lung cancer; Liver disease; Breast cancer which has spread to the bones; Epilepsy Migraine, headaches Psychiatric or emotional illness Prostatic complaints, such as problems with passing urine. any unusual or allergic reactions to androgens or anabolic steroids Sleep apnoea (temporarily stopping breathing during your sleep), this may get worse if you are using testosterone-containing products. Extra supervision by your doctor may be necessary in case you are overweight or suffer from chronic lung disease. Tell your doctor if you are on a special diet, e.g. low salt, lower sugar and you are taking any other medicines.
Caution: Before taking Andriol Testocaps it is also important to tell your doctor if you have or have ever had too much cholesterol or other fatty substances in the blood. Tell your doctor if you have been treated with other sex hormones recently. During long-term treatment with Andriol Testocaps regular medical checks, including prostate examination, are recommended. Extra supervision by a doctor is necessary in the treatment of young boys.
Taking other medicines Please tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines – even those not prescribed that you buy from your pharmacy, supermarket or healthfood shop. Other medicines may influence the effects of Andriol Testocaps, or Andriol Testocaps may affect other medicines. Therefore you must tell your doctor or pharmacist if you are taking (or intend to take) other medicines such as:- barbiturates, (medicines for epilepsy or sleeplessness) antidiabetic drugs cyclosporin Insulin and/or other medicines to control your blood sugar levels*Medicines to reduce the clotting of your blood (anti-coagulants)*
The use of androgens like Andriol Testocaps may lead to a reduction of the doses of these medicines.
Also tell your doctor or pharmacist if you are using or about to use the hormone ACTH or corticosteroids (used to treat various conditions such as rheumatism, arthritis, allergic conditions and asthma). The use of androgens like Andriol Testocaps may increase the risk of water retention especially if your heart and liver are not working properly. Andriol Testocaps may interfere with some laboratory tests (e.g for glucose tolerance, thyroid function and clotting factors). Therefore you must tell your doctor or the laboratory staff performing the tests that you are using this medicine. Andriol Testocaps are not intended for use in female patients. Therefore this medicine must not be taken by women who are pregnant or think that they are pregnant, or by women who are breast-feeding. In men, treatment with Andriol Testocaps can lead to fertility disorders by repressing sperm formation. If you are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. This medicine contains Sunset Yellow which may cause allergic reactions. Improper use: If you are a patient who participates in competitions governed by the World Anti-Doping Agency (WADA), then you should consult the WADA-code before using this medicine as Andriol Testocaps can interfere with anti-doping testing. The misuse of this medicine to enhance ability in sports carries serious health risks and is to be discouraged.
DOSING
Males over 18 years of age: The recommended dose of testosterone undecanoate androgel is 750 mg (3 ml) intramuscularly; followed by 750 mg (3 ml) intramuscularly after 4 weeks, then 750 mg (3 ml) intramuscularly every 10 weeks thereafter.
Safe and effective use of testosterone undecanoate is not determined for males under 18 years of age.
Do NOT use testosterone undecanoate if:
you are allergic to any ingredient in testosterone undecanoate androgel you are pregnant, planning to become pregnant, or are breast-feeding you have breast cancer or known or suspected prostate cancer
Contact your doctor or health care provider right away if any of these apply to you.
Trenbolone Enanthate is a19-nor steroid, very similar to Nandrolone. The primary difference between Trenbolone is that there is a double carbon bond present at the 9 and 11 position on the steran nucleus. Trenbolone can not aromatize to estrogen nor be 5a-reduced.
It bonds very tightly to the Androgen Receptor, and for this reason it is thought that much of its fat-burning and muscle building abilities are receptor mediated.
Administration
You have probably noticed that there is no “Technical Data” for Trenbolone Enanthate per se (all of the studies cited are actually on Trenbolone with a different ester)
Well…there’s a very good reason for that. As noted previously, trenbolone enanthate is a strictly underground product…so while you will easily be able to find it available from GA Labs or DL Pharmaceuticals INC., you will not find it available from UpJohn or Steris. In fact, at this point, you will only find Trenbolone (Acetate) available in the veterinary industry.
In my experience with Trenbolone Enanthate, it is a very potent cutting agent, and will even help keep you lean while on a bulking cycle (it did for me, anyway). However, it will also cause some undesirable effects as well. It can cause insomnia and night sweats, as well as possible anxiety. It seems to not cause “tren cough” (coughing associated with Trenbolone Acetate) but still seems to reduce cardiovascular ability.
All in all, though, Trenbolone (any ester) is a really great drug for both building muscle as well as burning fat. It’s probably most people’s favorite behind testosterone, side effects be damned…and for good reason.
If you’re not a competitive athlete, this is a really great drug. Bodybuilders love the stuff, and we see it in many pre-contest cycles now-a-days. Athletes need to avoid it, however, because it simply reduces cardiovascular output too greatly, probably due to prostaglandin induced bronchial constriction.
Dosages
Dose ranges for trenbolone vary greatly depending on the ester preparation being used and the desired effects of the user. Trenbolone acetate is injected every day or every other day, in dosages ranging from 50mg per injection to, as high as, 200mg per injection.
Steroid users who inject the enanthate or hexahydrobenzylcarbonate version will usually inject the product weekly. The longer ester allows for a slower release of the hormone; thus, the steroid can be injected less often and in higher amounts. Athletes that use the longer ester versions of this product will usually inject between 200mg to 600mg of the product per week.
The oral version of trenbolone 17alpha-methyl-trenbolone, is so powerful and toxic, that only 0.5mg to 2mg of the product are needed daily to see and feel noticeable results.
Side Effects of Trenbolone Enanthate:
Trenbolone Enanthate is not what we’d call the most side effect friendly anabolic steroid of all time. There are many possible side effects of Trenbolone Enanthate use, but possible is the key word. The side effects of Trenbolone Enanthate with one exception are not guaranteed. Many of the possible side effects are very similar to many other anabolic steroids and most should find they are very easy to control. However, there are certain response side effects of Trenbolone Enanthate that will keep many from being able to use this hormone. There will be more who cannot use the Trenbolone hormone perhaps more so than any anabolic steroid. However, the majority of men should still tolerate the hormone well despite a stronger number not being able to use it compared to most steroids. In order to help you understand the possible side effects of Trenbolone Enanthate, we have broken them down into their separate categories along with all the information you’ll need.
Out of all the injectable steroids available, Tren-E 200 is the one that should be used with extreme caution and only after plenty of research into its side effects and common cycles have been carried out. Trenbolone side effects can be very bad to many users, so much so that they will not use it despite its very positive effects on the body and strength. Firstly, as Tren-E 200 is so androgenic, all side effects that are seen with strong androgens can be expected with Tren-E 200. If one is prone to male pattern baldness (MPB) than trenbolone will likely speed this up. Some users find acne on trenbolone worse than when on any other steroid. Certainly Tren-E 200 is not recommended for female users due to its strong androgenic properties and the common side effects that manifest themselves in females who use strong androgens. The Side Effects of Tren-E 200 are similar to those of other testosterone compounds. Next to the high water retention other negative effects that are noticed are a sometimes strong acne and a distinctly increased aggressiveness in some users. An aggressive behavior can mostly be explained by the fact that athletes simply use too high a dosage of Tren-E 200 and too low a dosage of the other testosterones. The very severe acne, however, is only caused by Tren-E 200. Often no purulent pustules but many small pimples appear so that the athlete looks as if he has an allergy. This is not intended to discourage anyone but it is a fact that many athletes after a brief time develop an acne on their lower arm, upper arm, shoulder, chest, back, and also in their face which, during an earlier intake of Sustanon or Testosterone Enanthate, did not manifest itself.
[1] Estrogenic:
Trenbolone Enanthate is not estrogenic in that it does not aromatize. There is no testosterone to estrogen conversion with this hormone making water retention impossible due to use. However, the hormone does carry a strong progestin nature, which can make gynecomastia a concern, especially in sensitive individuals. When combined with the use of an aromatizing steroid, this appears to increase the risk. Progesterone has the ability to stimulate the estrogenic mechanism in the mammary tissue, which in turn can promote gynecomastia. In order to combat this issue, some men will need an anti-estrogen.
When it comes to Tren produced gynecomastia, there has been a prevailing myth that has been passed around message boards for years. The myth simply states that it’s the possible prolactin buildup caused by Trenbolone that leads to gynecomastia, but this simply isn’t true. William Llewellyn has largely dispelled this myth showing the intrinsic relationship between estrogen and progesterone imbalances and their effects on the mammary tissue. In his Anabolics series, you will find he goes into great detail explaining this issue.
[2] Androgenic:
Trenbolone Enanthate is highly androgenic, which can lead to acne, accelerated hair loss in those predisposed to male pattern baldness and body hair growth. The androgenic side effects of Trenbolone are, however, highly dependent on genetic predispositions. If you are not predisposed to male pattern baldness, losing any hair will be impossible. If you are not normally acne sensitive, the odds of any related problem during use is unlikely.
Those who are sensitive to the androgenic side effects of Trenbolone Enanthate will often attempt to combat them with a 5-alpha reductase inhibitor. This is very common and is also a waste of time. Such inhibitors, Finasteride being primary, are commonly used to reduce the androgenicity of a steroid that is brought on by a reduction of testosterone to dihydrotestosterone (DHT). This is all caused by the hormone being metabolized by the 5-alpha reductase enzyme, but Trenbolone is not metabolized by this enzyme. As a result, the use of any related inhibitor will have very little to no affect on the hormone’s androgenicity.
[3] Cardiovascular:
The possible cardiovascular side effects of Trenbolone Enanthate are by far the most concerning. In the present moment of use many are often far more concerned with gynecomastia, but this is merely a visual issue. Cardiovascular issues can directly and negatively affect your health. The primary area of concern will surround cholesterol. Tren can increased LDL cholesterol (bad cholesterol) levels and suppress/reduce HDL cholesterol (good cholesterol) levels. This cholesterol strain should not be as strong as many oral steroids, but potentially more severe than most injectable steroids.
In order to control your cholesterol, living a healthy lifestyle is imperative. A healthy lifestyle should include a cholesterol friendly diet that is low in saturated fats and simple sugars and abundant in omega fatty acids. Supplementing daily with large amounts of fish oils is normally advised. The individual should also ensure he implements plenty of cardiovascular activity on a regular basis and this includes off-season periods of growth. Do not buy into the idea that cardio is damaging to your off-season gains. You do not have to implement contest style cardio programs during your off-season but a regular amount for your health is recommended. This will, however, actually help you with off-season growth. It will keep your metabolism even stronger, minimize off-season fat gain and lead to a better physique. If you already have high cholesterol or cannot maintain a healthy cholesterol level during use you should not use this anabolic steroid.
Trenbolone Enanthate can also have a negative impact on blood pressure. The odds are in most men’s favor, especially since water retention, a primary promoter of high blood pressure is impossible with this steroid. However, high blood pressure is possible and you should keep an eye on it. Most healthy adult men will be fine if they live a healthy lifestyle.
[4] Testosterone:
All anabolic steroids will suppress natural testosterone production; however, the rate of suppression varies greatly from one steroid to the next. In the case of Trenbolone Enanthate, suppression will be dramatic and will not be affected by genetics. Due to the powerful rate of suppression all men who supplement with Trenbolone are strongly encouraged to include exogenous testosterone into their plan. Those who do not include exogenous testosterone will fall into a low testosterone state. Low testosterone comes with numerous possible symptoms. Sexually related symptoms are the most common, such as erectile dysfunction and suppressed libido, but they are far from the only ones. It is actually possible to suffer from low testosterone without sexually related symptoms and while the symptoms are not directly life threatening the condition is extremely unhealthy. The form of testosterone you choose is inconsequential. All that matters is you provide your body with this essential hormone.
Once the use of all anabolic steroids comes to an end natural testosterone production will begin again on its own. However, you will be at a low testosterone level for quite sometime. This can begin to produce low testosterone symptoms, which can include a loss of muscle mass and strength. It is very easy for cortisol to become dominant during this phase. For this reason, most men are encouraged to implement a Post Cycle Therapy (PCT) plan if they are going to be off-cycle for any decent length of time.
A PCT plan will stimulate natural testosterone production and greatly reduce the total recovery time. There is, however, no PCT plan on earth that will get you back to normal on its own, this will still take time. However, such a plan will ensure you have enough testosterone for proper bodily function while your levels continue to naturally rise.
Important notes on natural testosterone recovery; natural recovery assumes no prior low testosterone condition existed. It also assumes there was no severe damage done to the Hypothalamic-Pituitary-Testicular-Axis (HPTA) due to the improper use of anabolic steroids.
[5] Hepatotoxicity:
Trenbolone Enanthate is not what we’d traditionally consider a hepatotoxic anabolic steroid. However, there does appear to be a level of toxicity associated with extremely high doses, but such doses are extremely high and far beyond what even most hardcore bodybuilders would attempt. The average Trenbolone user should not experience any hepatic stress or damage.
[6] Effects:
There are four possible side effects of Trenbolone Enanthate that are 100% based on individual response and the subject of numerous myths surrounding the hormone. The effects have become such a topic of debate on many message boards that some believe if you don’t experience them your Tren must be no good. Not only is this ridiculous but it’s a borderline insane way of thinking. Successful use of any anabolic steroid not only refers to progress made but progress made without side effects or issues of concern. However, it will be the response based side effects of Trenbolone Enanthate that will keep some men from being able to use this hormone. In some cases, lowering the dose can fix the problem, but many who suffer will find that such effects occur even at low doses. The response effects include anxiety, insomnia, night sweats and rapid heart rate. They can also be so strong that they become unbearable. If a low dose of Tren causes such effects in you the hormone is probably not for you. If such effects occur, the best course of action is to discontinue use and try again later on at a lower dose. If problems still occur, this hormone is in no way for you. That may seem unfair but it’s life. Everyone has varying reactions to various hormones, medicines and even foods.
Because of the possible response side effects of Trenbolone, Trenbolone Enanthate is not recommended for first time users. Your first go with the hormone should always be Trenbolone Acetate, which most will prefer anyway. However, if you choose the Enanthate version your first time, run into problems and discontinue use you will still have to wait every bit of three weeks or more for the effects to dissipate. If you choose the Acetate version and run into problems, you can discontinue use and see them fade in a few days.
Why Choose Trenbolone-Enanthate?
The Trenbolone hormone is perfect for any cycle, for other than testosterone there is no anabolic steroid that is as versatile. Tren can provide excellent buildups in mass and strength, lean your physique out, enhance conditioning, preserve tissue and promote recovery quite unlike any anabolic steroid. All Trenbolone forms can do the same, so the question it hand is why choose Trenbolone-Enanthate? Right off the bat we can tell you if you’ve never supplemented with Tren before you need to start with the Acetate ester. If you’ve never supplemented before, there’s no way to know how well you’ll respond to the hormone, and if you respond poorly you don’t want to be supplementing with Trenbolone-Enanthate. If harsh side-effects occur and you’re supplementing with the Enanthate version, you will have to wait several weeks for them to dissipate after use is discontinued. Conversely, if you’re supplementing with the small ester Acetate, if side-effects become problematic you can discontinue use and see them dissipate in only a few days.
Again, it begs the question, why supplement with Trenbolone-Enanthate over other Tren forms? The only reason one would choose the Enanthate version over any other Tren form is based on injection frequency. If you supplement with Trenbolone-Acetate, you’re going to have to inject on an every other day basis. Some will even inject on a daily basis due to the short half-life, but every other day is more than sufficient. If you supplement with Parabolan, you’re going to find a 2-3 times per week schedule to be warranted, with 3 times per week being optimal. However, Parabolan is extremely expensive, the original is no longer made, and this form is commonly counterfeited and simply not as available as the Acetate version. At any rate, if you choose Trenbolone-Enanthate you’ll be able to limit yourself to two injections per week. In truth, you might be able to get by with one injection every five days, but two times per week will be optimal. In any case, there is truly no true advantage over this version of Tren in-terms of direct performance, and anyone who claims there is has suffered from some placebo type effect, or simply doesn’t know what they’re talking about.
Tren Enanthate PCT
After you run a Trenbolone Enanthate cycle, you will definitely want to start a post-cycle therapy (PCT). Post-cycle therapies seek to restore the body’s hormone balance by allowing the natural production of testosterone to return to normal levels. In PCT, the use of aromatase inhibitors and Selective Estrogen Receptor Modulators (SERM) accomplishes this goal.
Clomid and Novaldex are two examples of the drugs you’ll take. How much and for how long depends on the length of your Trenbolone Enanthate cycle and the size of the dosage of Tren E.
Trenbolone Enanthate was never prescribed clinically for use in humans, though a French pharmaceutical company developed a different ester of Trenbolone for use in humans, which is no longer produced. The existing use is strictly in veterinary uses, which should alert you to be extremely cautious in using the drug to avoid Trenbolone Enanthate side effects. When you finally buy your Trenbolone pills or injection, ask the supplier to provide safety instructions for using their product.
Half-life
On it’s own, the base trenbolone hormone has a half-life of about 6-8 hours. Although not many bodybuilders use the base hormone. Most athlete are injecting a version of trenbolone that has an ester chain attached to it, and it is not until plasma lipases in the blood stream cleave off the ester chain that trenbolone is free to interact with androgen receptors in muscle cells. The active half-life of the acetate ester version is of about 48 hours, while the enanthate version is about 5-7 days. The Hexahydrobenzylcarbonate (Cyclohexylmethylcarbonate) ester chain being the longest at 8-10 days. Though, due to the lack of scientific consensus, some of these figures can be off by about 10-20%.
Trenbolone hexahydrobenzylcarbonate is a slow-acting injectable ester of the potent anabolic steroid Trenbolone. Trenbolone appears most commonly as trenbolone acetate, which is a much faster-acting form of the drug. The hexahydrobenzylcarbonate ester used here extends the release of Trenbolone for more than 2 weeks, which has always been thought of as more suitable for human use due to the less frequent injection schedule. The base steroid Trenbolone is roughly three times more androgenic than testosterone, making it a fairly potent androgen. It also displays about 3 times greater tissue-building activity in comparison to its androgenic properties, making its official classification as that of an anabolic steroid. The musclebuilding effect of Trenbolone Acetate is often compared to such popular bulking agents as testosterone or Dianabol, but without the same estrogen related side effects. It is most commonly identified as a lean-mass-building drug, and is extremely popular with athletes for its ability to promote the rapid buildup of strength, muscle size, and definition.
Trenbolone is not what we’d call the most side effect friendly anabolic steroid. Side effects of Trenbolone are undoubtedly possible, but they are often blown way out of proportion. This is a common practice by those who hold to an anti-steroid sentiment, but in the case of the side effects of Trenbolone it’s often steroid users who are the biggest offenders. This steroid will carry some very common possible steroid side effects. However, it will also carry a few that while possible tend to be a bit unique to the Trenbolone hormone. Such effects are highly dependent on response. Dose can play a role but response is the primary factor. Because these effects will be pronounced strongly many have begun to inaccurately assume that their Trenbolone is no good if such effects do not occur. This is an insane way of thinking. Others assume the steroid should not be used unless you have years of anabolic steroid experience. Again, this is insane thinking. If you are a poor responder you’ll be a poor responder in your first year of steroid use or your twentieth. In order to understand the side effects of Parabolan, we have separated them into their respected categories along with everything you need to know.
Estrogenic effects of Trenbolone
Trenbolone does not aromatize and carries no estrogenic activity. However, estrogenic side effects are still possible with this steroid due to a strong progestin nature. Water retention will not be a concern, but gynecomastia will be possible in some men depending on sensitivity. While there is no estrogenic activity, progesterone has the ability to simulate the estrogenic mechanism in the mammary tissue leading to gynecomastia. In order to protect from such action, some men may need an anti-estrogen medication, but many will be fine without it. Again, sensitivity will be the primary issue. Androgenic:
The Trenbolone hormone is highly androgenic, and as a result, the side effects of Parabolan can include strong related effects. Such side effects of Trenbolone include acne, accelerated hair loss in those predisposed to male pattern baldness and body hair growth. Such effects will be linked to genetic predispositions but they are quite possible in many men who use the hormone. To combat such side effects, some will be tempted to use a 5-alpha reductase inhibitor. However, the Trenbolone hormone is not metabolized by the 5-alpha reductase enzyme and related inhibitors will have no notable affect in reducing the androgenicity of the hormone.
Due to the androgenic nature of Trenbolone, virilization symptoms are very possible when women supplement with this steroid. Virilization symptoms can include body hair growth, a deepening of the vocal chords and clitoral enlargement. Most women who use this steroid will experience such symptoms at some level even with low doses. It is very possible to reverse such symptoms if use is discontinued at their onset, but they will often become permanent if allowed to set in. For this reason, most women are encouraged to seek out steroids with lower virilization ratings if anabolic steroids are to be used. Such compounds commonly include Anavar (Oxandrolone) and Primobolan (Methenolone) as well as Winstrol (Stanozolol) and possibly Equipoise (Boldenone Undecylenate) at low doses.
Effects
Parabolan can have a notable adverse effect on cholesterol. It’s not as strong as many anabolic steroids, especially most oral steroids but it is notable enough. High blood pressure is also possible, but cholesterol will be the primary issue. For this reason a healthy lifestyle, one that is cholesterol friendly is imperative when supplementing with the Trenbolone hormone. If you already suffer from high cholesterol or blood pressure you should not use this steroid. If you are healthy enough for use, you should ensure your diet is cholesterol friendly, low in saturated fats and simple sugars and rich in omega fatty acids. You should also ensure you include plenty of cardiovascular training into your routine. Maintaining your health is very important when using anabolic steroids and it is more than possible with this steroid, but it will take some effort on your part. Testosterone:
All anabolic steroids suppress natural testosterone production. However, the rate of suppression varies greatly from one steroid to the next. In the case of Trenbolone the rate of suppression will be extreme. For this reason, all men who supplement with Parabolan are encouraged to include exogenous testosterone in their plan. Failure to include exogenous testosterone will result in a low testosterone condition. Such a condition can come with numerous bothersome symptoms that can affect your physical, mental and sexual wellbeing. Many inaccurately assume if they do not suffer from the sexually related symptoms their levels are not low, but this simply isn’t true. Further, such a condition is extremely unhealthy. Including exogenous testosterone is imperative.
Once all anabolic steroid use comes to an end, your natural testosterone production will begin again. At the conclusion of the cycle, most are encouraged to implement a Post Cycle Therapy (PCT) plan. This will stimulate natural production to a greater rate and greatly reduce the overall recovery time. It will not bring your levels back to normal on its own. There’s no PCT plan on earth that can do this. However, it will improve the recovery rate and ensure you have enough testosterone for proper bodily function while your levels continue to naturally rise.
An important note, natural recovery assumes no prior existing low testosterone condition. It also assumes no severe damage was done to the Hypothalamic-Pituitary-Testicular-Axis (HPTA) due to improper use or irresponsible supplementation practices. Hepatotoxic:
The Trenbolone hormone is generally not a hepatotoxic steroid. A level of toxicity is possible but appears to be limited to extremely high doses of the steroid. Most who use Parabolan will not experience any stress or damage to the liver.
Results
The final side effects of Parabolan include four reactions that are predominantly due to a poor response to the hormone. If you are a positive responder, it may be possible to fall prey to such effects with extremely high doses. However, a true negative responder will often find such effects occur regardless of the dose. The response base side effects of Parabolan include anxiety, insomnia, night sweats and rapid heart rate, and they can be very extreme. They can be so pronounced there will be some who cannot use the Trenbolone hormone. While most men will tolerate the hormone fairly well, more men will not be able to use Trenbolone more so than most anabolic steroids.
Due to the response side effect of Parabolan, when you use the Trenbolone hormone for the first time the only one you should use is Trenbolone Acetate. If the response effects occur at a high rate, you can discontinue use and they will fade away in a few days. If you are using Parabolan, due to its large ester you will have to wait a few weeks for the adverse effects to dissipate even after discontinuation. Strongest Anabolic Steroid
You probably are familiar with other mass building products such as testosterone. This hormone is known to be quite effective and helps many athletes, bodybuilders as well as weightlifters bulk up fast and maintains their agility.
But, did you know that Parabolan is much stronger than testosterone? When stacked, its androgenic properties are five times as strong as testosterone while its anabolic scores are four times better than testosterone. Consuming 200mg of Trenbolone will have same effects as consuming 1000mg of testosterone.
Parabolan Functions & Traits:
Parabolan, officially labeled Trenbolone Hexahydrobenzylcarbonate is a structurally altered form of Nandrolone. Deca being the hormone most commonly associated with Deca Durabolin (Nandrolone Decanoate). For the Trenbolone hormone to exist, the Nandrolone hormone has an added double bond at carbon positions 9 and 11. This greatly increases the hormones androgen binding affinity and inhibits the hormone from aromatizing. Parabolan carries no aromatizing nature. This slight modification also slows down the metabolism of the hormone resulting in a far more potent anabolic and androgenic nature than Nandrolone, far beyond testosterone as well. In order to understand this hormone’s power, consider its anabolic and androgenic ratings. Trenbolone carries an anabolic rating of 500 as well as an androgenic rating of 500. All steroids carry a rating measured against the rating of testosterone, which carries a rating of 100 in both categories. More importantly, the Trenbolone hormone’s ratings match up perfectly to its translating activity. This is not always the case as can be seen in steroids like Halotestin (Fluoxymesterone) and Proviron (Mesterolone) to name a few. You will be hard pressed to find an anabolic steroid that carries the raw anabolic and androgenic power of Parabolan.
As an anabolic steroid, Parabolan carries with it numerous common steroidal traits associated with anabolic power. Many of these traits are shared by many other anabolic steroids, but in the case of the Trenbolone hormone it carries them with a far greater rate of power. This steroid has the ability to enhance protein synthesis and nitrogen retention in the muscles far more so than most steroids. This is important as protein synthesis refers to the rate by-which cells build proteins. As proteins are the building blocks of muscle, this promotes a potent anabolic atmosphere. The enhanced rate of nitrogen retention again promotes this atmosphere and protects the body from catabolism. All lean muscle tissue is comprised of approximately 16% nitrogen and a deficiency will lead to a catabolic state.
Parabolan also has the ability to greatly increase red blood cell count and IGF-1 output. The increased red blood cell count is important as red blood cells are responsible for carrying oxygen to and through the blood. This not only promotes greater muscular endurance, but again revs up the total anabolic activity. When it comes to anabolic activity, this is precisely why the increased presence of IGF-1 is important. IGF-1 is a powerfully potent anabolic hormone that affects nearly every cell in the human body. This simple hormone also plays a tremendous role on our body’s recovery process.
The Trenbolone hormone is also well noted for being one of the best inhibitors of glucocorticoid hormones or stress hormones like cortisol. These hormones are in many ways the complete opposite of anabolic steroids in that they destroy muscle tissue and promote fat storage. With this trait, along with the insanely potent anabolic atmosphere, the individual should find a greatly enhanced metabolic rate. However, he should also find steroids like Parabolan also have the ability to directly promote lipolysis due to its tremendous binding affinity for the androgen receptor. Most all anabolic steroids can promote an enhanced metabolic rate, but very few tend to support direct fat loss and Parabolan tends to promote it at a notable rate.
All of the mentioned traits make Parabolan a remarkable anabolic steroid, but it carries another that truly separates the Trenbolone hormone from the rest of the pack. This anabolic steroid has the ability to remarkably increase feed efficiency or nutrient efficiency. This is the very reason Fina pellets are administered to cattle shortly before slaughter in order to beef them up for a higher return on the market. By increasing feed efficiency, this makes every last nutrient more valuable than it would be otherwise. Every gram of protein, fats and carbohydrates we consume is utilized at a higher rate, less is wasted and a greater benefit is gained. A good way to look at it is as you would the money in your pocket. Imagine being able to buy ten dollars worth of goods and services with every one-dollar you have. Perhaps a slight oversimplification, but it’s not that far off.
Administration
Men
Trenbolone hexahydrobenzylcarbonate was generally administered in a clinical dosage of 3 ampules per month. Therapy was initiated the first month with all 3 ampules given over the first 15 days. During the subsequent 3 months, one injection (76 mg) was given every 10 days. For physique- or performance-enhancing purposes, trenbolone hexahydrobenzylcarbonate is most often administered at a dosage of 152-220 mg per week. The drug would be taken in cycles ranging from 6 to 12 weeks. Although a weekly administration schedule would be more than sufficient, athletes usually injected a single ampule (76mg) at a time, and the total amount would be spread evenly throughout the week. Although not necessary, this type of schedule helps to reduce injection volume per application. The results with the use of trenbolone hexahydrobenzylcarbonate should be a visibly more muscular physique (larger, leaner), and, if body fat levels are low enough, that hard ripped look most valued by dieting and competitive bodybuilders. While this drug is quite potent when used alone, it is sometimes combined with other steroids for an even greater effect. Leading up to a show one could successfully add a non-aromatizing anabolic such as Winstrol® or Primobolan®. Such combinations will elicit a greater level of density and hardness to the build, often proving dramatic for a stage appearance. We could also look for bulk with this drug, and addition stronger compounds like Dianabol or Testosterone. While the mass gain would be quite formidable with such a stack, some level of water retention would probably also accompany it. Moderately effective anabolics such Deca-Durabolin® or Equipoise® would be somewhat of a halfway point, providing extra strength and mass but without the same level of water bloat we see with more readily aromatized steroids.
Women
Trenbolone hexahydrobenzylcarbonate was generally administered in a clinical dosage of 3 ampules per month. Therapy was initiated the first month with all 3 ampules given over the first 15 days. During the subsequent 3 months, one injection (76mg) was given every 10 days. Given the risk of virilization, lower doses were likely used by physicians with many female patients. This agent is generally not recommended for women for physique- or performanceenhancing purposes due to strong androgenic nature and tendency to produce virilizing side effects.
FINAL DECISION: Highly Effective!
Very few hormones come close to Parabolan when it comes to muscular gains, improved performance and effectiveness. Coming with half-life of about 8 days, the hormone will remain in the system for a longer period compared to other varieties such as Tren Acetate (3 days) meaning that you will continue to experience the effects for a longer time.
Clenbuterol is one of the most widely used fatburners for other players and also bodybuilders. It serves as bronchodilator for people who suffer with asthma to produce breathing more easy. But it is used by bodybuilders because of the fat qualities that are burning of it’s.
There are various different weight-loss medications employed by athletes such as for example, T3 and Ephedrine.
Ephedrine which leaves your body in just a few hrs, Clenbuterol keeps for days, but although clenbuterol emergency towards the receptors because the common fat loss substance Ephedrine. Which means that Clenbuterol is active in your body all of the 24 hours per day thus creating Clenbuterol more efficient.
Ephedrine accelerates not the guts fee less-than clenbuterol and it can be used in higher dosage.
It is best to utilize Clenbuterol for shorter periods of time, like a couple of weeks down and two weeks on and after that repeat. This tactic can be used since the human body are certain to get used-to the medication rapidly and rendering it less successful, therefore it is not unwise allow the body sleep and to come of for two months.
A normal Clenbuterol period starts with 40 mcg daily and improves every 3rd of 4-day and soon you reach a serving that you are more comfortable with. Generally people go-to 120 mcg or 160 mcg may be gone up to by some consumers that are more knowledgeable.
After you buy Clenbuterol it boosts metabolic rate and increases fat loss as it also enhances athletic performance. It has to be used in the right manner and prescriptions for it to work as desired. It also stimulates Beta-2 receptors which increase metabolism and heat production in the body.
Your diet has to be altered to achieve the effects of Clenbuterol since it only stimulates metabolism. It does not directly melt the fat away. The weight loss is caused by metabolic stimulation that produces fat burning effect.
Clenbuterol bodybuilding in other words, is very flexible and can be used in the cutting and bulking phases. The question of which is better, gel or tablet, will continue on and in the end, what really matters is where you buy these and how you use it.
With the help of the enzyme aromatase testosterone is able to turn into the most powerful estrogen – estradiol. The aim of anti-estrogen drugs is to prevent such conversion. These drugs include anastrozole (another name – Arimidex).
If you are taking anabolic steroids, this medication can help to minimize the side effects of increasing the estrogen levels. This medicine as efficiently controls the level of estrogen.
It is necessary to highlight the unique properties of anastrozole – for example, an increase in free testosterone. By the way, the drug works relatively fast. The maximum concentration of active substance in the blood observed after a couple of hours after the receiving means. This allows you to quickly suppress the process of flavoring.
Action of Anastrozole
Arimidex is the perfect companion during hormone replacement therapy.
The drug holding estrogen low, which prevents prostate enlargement.
Against reception means testosterone is produced in a natural way, even while taking anabolic-androgen.
Anastrozole in bodybuilding – active assistant in the protection of gynecomastia.
The drug is mild on blood lipids.
Representatives of the stronger sex have noted that while the use of anastrozole increases libido.
This is the most popular drug for post-cycle therapy in the recovery period.
Through use of the drug, reduced water and fat accumulation during the course of the steroid. It is because of this often misused antiestrogens athletes to compensate for a poor diet, or the consequences of a wrong cycle of anabolic steroids.
Even in minimal doses Anastrozole is able to control the level of estrogen. This is an effective and safe drug. With regard to high doses, they are assigned to courses with vysokoaromatiziruyuschimisya steroids, for example, Danabol. With Anavar or Primobolan quite small doses of the drug.
Anastrozole: application and dosage
Newcomers this tool should not be used. Tablets intended for experienced athletes, after they have been receiving long cycle anabolic steroids in high doses. Anastrozole is administered in two cases before the course of steroids as a prophylactic with therapeutic doses, and after the course, if there are any side effects.
The cycle time of reception of the funds must be no more than 14 days. During this time, the drug is manifested all its useful properties. Take tablets on an empty stomach and drink plenty of water – so the active ingredient quickly went from the gastrointestinal tract into the bloodstream.
This means you need to eat on a strict schedule. One day, taking second – rest. Accepted at any time of the day. Sufficient good results for a dose of 250 micrograms once a couple of days. It is proved that in order to reduce the level of estradiol in the 50% required dose of 0.5 to 1 milligram.
During the cycle, it is necessary to take into account the fact that not all anabolic steroids aromatize. At risk are the testosterone esters. As for methandrostenolone and Anadrol, they are only slightly converted into estrogen.
If the loop includes long esters, for example, Sustanon, you should be tested for estradiol 3-4 weeks after steel to make “chemistry.” Generally it is best to check analysis carried out in about 10-14 days from the time you started taking anastrozole. So you can adjust the required dose.
Those athletes who started gynaecomastia, positive about the drug anastrozole. The same applies to letrozole. These drugs effectively relieve symptoms of growth of mammary glands during the course of anabolic steroids.
If there are problems of the cardiovascular system can not take the medicine. The fact that the device effectively prevents the side effects of estrogen, but blocks and its useful properties.
As a result, there may be problems with the heart and blood vessels. If athletes have similar diseases, it is imperative to consult a sports doctor, or used tamoxifen.
